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- W2292583204 abstract "synergistic, as previously shown with the higher dose of IND/GLY (12). Methods to evaluate synergy in pharmacology include the Bliss Independence Criterion, which can be used in assessing the contributions of each agent. Synergy maybe more advantageous in clinical effectiveness, as lower doses reduce the incidence of drug resistance and tolerance and reduce adverse effects, but it is complicated; Drugs may be additive or synergistic at different times after administration, such as in the first few minutes or on the upstroke of the dose–response curve or when employing suboptimal doses. Because clinicians must choose between monotherapies with LABAs or LAMAs or LABA/LAMA FDCs in initiating therapy for symptomatic, and especially nonexacerbating, patients with COPD, often a 1- to 3-month empiric trial is begun. IND/GLY shows consistently more benefi ti n lung function and PRO than monotherapy, suggesting better clinical outcomes. Another clinically relevant question to be answered is whether the combination could still work when there is little or no effect from one component or even both. Could synergy be an important mechanism leading to clinical benefit in these situations? Important questions remain to be answered. n" @default.
- W2292583204 created "2016-06-24" @default.
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- W2292583204 date "2015-01-01" @default.
- W2292583204 modified "2023-09-27" @default.
- W2292583204 title "Ultrasonographic Monitoring of the Diaphragm during Mechanical Ventilation: The Vital Pump Is Vivid, Plastic, and Vulnerable" @default.
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