FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292610516> ?p ?o ?g. }

• W2292610516 endingPage "13327" @default.
• W2292610516 startingPage "13319" @default.
• W2292610516 abstract "// Lei Cao 1,* , Hui-Fu Wang 1,* , Lin Tan 2 , Fu-Rong Sun 3 , Meng-Shan Tan 3 , Chen-Chen Tan 3 , Teng Jiang 4 , Jin-Tai Yu 1 , Lan Tan 1,2,3 and Alzheimer’s Disease Neuroimaging Initiative 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China 2 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China 3 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China 4 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China * These authors have contributed equally to this work Correspondence to: Lan Tan, email: // Jin-Tai Yu, email: // Keywords : Alzheimer’s disease, brain structure, HMGCR, neuroimaging, glucose metabolism, Gerotarget Received : November 25, 2015 Accepted : February 11, 2016 Published : February 29, 2016 Abstract Alzheimer’s disease (AD) has become a considerable public health issue. The mechanisms underlying AD onset and progression remain largely unclear. 3-Hydroxy-3-methylglutaryl coenzyme A reductase ( HMGCR ) is a strong functional AD candidate gene because it encodes part of the statin-binding domain of the enzyme, which serves as the rate-limiting step in cholesterol synthesis in all mammalian cells. Here, we evaluated the potential role of HMGCR (rs3846662) in AD-related pathology by assessing neuroimaging biomarkers. We enrolled in 812 subjects from the Alzheimer’s disease Neuroimaging Initiative dataset. In general, it is possible that HMGCR (rs3846662) could be involved in preventing the atrophy of right entorhinal (P=0.03385) and left hippocampus (P=0.01839) in the follow-up research of two years. What’s more, it lowered the drop rate of glucose metabolism in right temporal. We then further validated them in the AD, mild cognitive impairment (MCI), normal control (NC) sub-groups. All the results in the MCI groups confirmed the association. The results of our study indicated that HMGCR (rs3846662) plays a vital role in AD pathology mainly by influencing brain structure and glucose metabolism during AD progression." @default.
• W2292610516 created "2016-06-24" @default.
• W2292610516 creator A5003518754 @default.
• W2292610516 creator A5025029753 @default.
• W2292610516 creator A5035352293 @default.
• W2292610516 creator A5037071314 @default.
• W2292610516 creator A5046396640 @default.
• W2292610516 creator A5057567249 @default.
• W2292610516 creator A5060887077 @default.
• W2292610516 creator A5063229278 @default.
• W2292610516 creator A5080305240 @default.
• W2292610516 creator A5087649543 @default.
• W2292610516 date "2016-02-29" @default.
• W2292610516 modified "2023-10-18" @default.
• W2292610516 title "Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts" @default.
• W2292610516 cites W1484890431 @default.
• W2292610516 cites W159735324 @default.
• W2292610516 cites W1787715269 @default.
• W2292610516 cites W1797408175 @default.
• W2292610516 cites W1904978935 @default.
• W2292610516 cites W1969787718 @default.
• W2292610516 cites W1975806945 @default.
• W2292610516 cites W1976076281 @default.
• W2292610516 cites W1990132589 @default.
• W2292610516 cites W2002076945 @default.
• W2292610516 cites W2004388421 @default.
• W2292610516 cites W2011358263 @default.
• W2292610516 cites W2037929460 @default.
• W2292610516 cites W2047426024 @default.
• W2292610516 cites W2048542414 @default.
• W2292610516 cites W2057920800 @default.
• W2292610516 cites W2060102465 @default.
• W2292610516 cites W2074692726 @default.
• W2292610516 cites W2075061360 @default.
• W2292610516 cites W2078524519 @default.
• W2292610516 cites W2081808793 @default.
• W2292610516 cites W2101135654 @default.
• W2292610516 cites W2107707255 @default.
• W2292610516 cites W2118117810 @default.
• W2292610516 cites W2121369614 @default.
• W2292610516 cites W2135147724 @default.
• W2292610516 cites W2155513557 @default.
• W2292610516 doi "https://doi.org/10.18632/oncotarget.7797" @default.
• W2292610516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4924644" @default.
• W2292610516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26950278" @default.
• W2292610516 hasPublicationYear "2016" @default.
• W2292610516 type Work @default.
• W2292610516 sameAs 2292610516 @default.
• W2292610516 citedByCount "5" @default.
• W2292610516 countsByYear W22926105162018 @default.
• W2292610516 countsByYear W22926105162019 @default.
• W2292610516 countsByYear W22926105162022 @default.
• W2292610516 countsByYear W22926105162023 @default.
• W2292610516 crossrefType "journal-article" @default.
• W2292610516 hasAuthorship W2292610516A5003518754 @default.
• W2292610516 hasAuthorship W2292610516A5025029753 @default.
• W2292610516 hasAuthorship W2292610516A5035352293 @default.
• W2292610516 hasAuthorship W2292610516A5037071314 @default.
• W2292610516 hasAuthorship W2292610516A5046396640 @default.
• W2292610516 hasAuthorship W2292610516A5057567249 @default.
• W2292610516 hasAuthorship W2292610516A5060887077 @default.
• W2292610516 hasAuthorship W2292610516A5063229278 @default.
• W2292610516 hasAuthorship W2292610516A5080305240 @default.
• W2292610516 hasAuthorship W2292610516A5087649543 @default.
• W2292610516 hasBestOaLocation W22926105161 @default.
• W2292610516 hasConcept C118552586 @default.
• W2292610516 hasConcept C126322002 @default.
• W2292610516 hasConcept C143998085 @default.
• W2292610516 hasConcept C16568411 @default.
• W2292610516 hasConcept C2779134260 @default.
• W2292610516 hasConcept C58693492 @default.
• W2292610516 hasConcept C71924100 @default.
• W2292610516 hasConceptScore W2292610516C118552586 @default.
• W2292610516 hasConceptScore W2292610516C126322002 @default.
• W2292610516 hasConceptScore W2292610516C143998085 @default.
• W2292610516 hasConceptScore W2292610516C16568411 @default.
• W2292610516 hasConceptScore W2292610516C2779134260 @default.
• W2292610516 hasConceptScore W2292610516C58693492 @default.
• W2292610516 hasConceptScore W2292610516C71924100 @default.
• W2292610516 hasIssue "12" @default.
• W2292610516 hasLocation W22926105161 @default.
• W2292610516 hasLocation W22926105162 @default.
• W2292610516 hasLocation W22926105163 @default.
• W2292610516 hasLocation W22926105164 @default.
• W2292610516 hasOpenAccess W2292610516 @default.
• W2292610516 hasPrimaryLocation W22926105161 @default.
• W2292610516 hasRelatedWork W1948571096 @default.
• W2292610516 hasRelatedWork W2003093540 @default.
• W2292610516 hasRelatedWork W2012176677 @default.
• W2292610516 hasRelatedWork W2152525601 @default.
• W2292610516 hasRelatedWork W2170376428 @default.
• W2292610516 hasRelatedWork W2462255595 @default.
• W2292610516 hasRelatedWork W2740299837 @default.
• W2292610516 hasRelatedWork W2803278045 @default.
• W2292610516 hasRelatedWork W2899967672 @default.
• W2292610516 hasRelatedWork W4323921342 @default.
• W2292610516 hasVolume "7" @default.
• W2292610516 isParatext "false" @default.

• next