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- W2292691569 abstract "Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on the integrity of the hepatocyte mass, this uptake can be quantified to assess liver function. We report the relationship between the extent of Gd-EOB-DTPA uptake and the degree of liver fibrosis. T1-weighted volumeinterpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before and 20 minutes after contrast injection. Strong correlations of the uptake characteristics of GdEOB-DTPA with the relative enhancement (RE) of the liver parenchyma and the grade of fibrosis/ cirrhosis, classified using the Ishak scoring system, were observed. The subdivisions between the grades of liver fibrosis based on RE were highly significant for all combinations, and a ROC revealed sensitivities ≥82% and specificities ≥87% for all combinations. MR imaging is a satisfactorily sensitive method for the assessment of liver fibrosis/cirrhosis." @default.
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- W2292691569 date "2015-01-01" @default.
- W2292691569 modified "2023-09-26" @default.
- W2292691569 title "Liver fibrosis and Gd-EOB-DTPA- enhanced MRI: A histopathologic" @default.
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