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- W2292755480 abstract "Delusional disorder has been the subject of very little investigation using brain imaging.To examine potential structural and/or functional brain abnormalities in this disorder.We used structural imaging (voxel-based morphometry, VBM) and functional imaging (during performance of the n-back task and whole-brain resting connectivity analysis) to examine 22 patients meeting DSM-IV criteria for delusional disorder and 44 matched healthy controls.The patients showed grey matter reductions in the medial frontal/anterior cingulate cortex and bilateral insula on unmodulated (but not on modulated) VBM analysis, failure of de-activation in the medial frontal/anterior cingulate cortex during performance of the n-back task, and decreased resting-state connectivity in the bilateral insula.The findings provide evidence of brain abnormality in the medial frontal/anterior cingulate cortex and insula in delusional disorder. A role for the former region in the pathogenesis of delusions is consistent with several other lines of evidence." @default.
- W2292755480 created "2016-06-24" @default.
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- W2292755480 date "2016-02-01" @default.
- W2292755480 modified "2023-10-18" @default.
- W2292755480 title "Structural and functional brain changes in delusional disorder" @default.
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- W2292755480 doi "https://doi.org/10.1192/bjp.bp.114.159087" @default.
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