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- W2292760273 abstract "Using Tg2576 transgenic mice that produce endogenous beta-amyloid (Aβ) protein in brain, we have previously reported that high dose of folic acid supplemented to Alzheimer drug memantine (MT)-treated AD mice significantly improved the neuronal functional performance on Morris water maze test. To further study effects of folate on the brain gene expression profile of MT-treated transgenic mice, a total of 6 Aβ mice brains (3 from MT mice and 3 from folate+MT mice) were analyzed by cDNA microarrays. Total RNA isolation, cDNA synthesis and cy3 and 5 dye labeling were performed using standard protocols. The labeled samples were hybridized to Agilent Whole Mouse Genome Oligo Microarray containing 41,000+ annotated genes and transcripts. Expression data were analyzed using GeneSpring GX 10. Only genes with net expression changes of > 2-fold occurring among 20-100th percentile of expression levels in each hybridized arrays were considered for further analysis. Compared to MT-treated Aβ mice brains, folate+MT brains showed a generalized up-regulation of 72 brain gene transcriptions involving in neurogenesis, memory, action potential production, neurotransmitter receptors, vasodilation, and immune modulation. Down regulations were only found in 9 transcripts. Validation of gene expressions by real-time PCR and the significance of modulated expression profiles by folate will be further discussed." @default.
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- W2292760273 date "2009-04-01" @default.
- W2292760273 modified "2023-09-23" @default.
- W2292760273 title "Effects of folate on the brain gene expression of Tg2576 transgenic mice treated with Alzheimer drug memantine: a pilot study using cDNA microarray profiling" @default.
- W2292760273 doi "https://doi.org/10.1096/fasebj.23.1_supplement.904.7" @default.
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