Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292812467> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2292812467 abstract "Previous pharmacological studies have provided conflicting results regarding the relevance of PPARγ in photobiology. In these current studies, we utilize a cytokeratin 14 promoter driven CRE-LoxP strategy to examine how loss of epidermal PPARγ (KO mice) alters ultraviolet B (UVB) responses in mouse skin. We first demonstrate an increase in PPARγ ligand production in lipid extracts of mouse epidermis irradiated with 1500 J/m2 of UVB. We next show that after 24 hrs, KO mice exhibit a marked increase (> 4-fold) in UVB-induced apoptosis as measured by epidermal caspase 3 activity. We next assessed UVB-induced inflammatory responses. At 24 and 72 hrs post-irradiation, KO mice exhibited increased inflammation as determined by significant increases in skin thickness, myeloperoxidase activity and inflammatory cell infiltrates. Given that inflammatory infiltrates typically occur at 36–48 hrs post-UVB, these studies suggest an earlier onset of inflammation in KO mice. Finally, in data unrelated to UVB irradiation, adult KO mice also exhibited almost complete loss of sebaceous glands. This data provides compelling evidence that epidermal PPARγ serves an important role in regulating the acute epidermal photoresponse and is necessary for sebaceous gland development and/or maintenance. Supported by funding by the National Institutes of Health and the Prevent Cancer Foundation." @default.
- W2292812467 created "2016-06-24" @default.
- W2292812467 creator A5016216262 @default.
- W2292812467 creator A5028890075 @default.
- W2292812467 creator A5032644073 @default.
- W2292812467 creator A5066441448 @default.
- W2292812467 date "2010-04-01" @default.
- W2292812467 modified "2023-09-26" @default.
- W2292812467 title "Mice deficient in epidermal PPARγ exhibit loss of sebaceous glands as well as augmented apoptosis and inflammation in response to ultraviolet B" @default.
- W2292812467 doi "https://doi.org/10.1096/fasebj.24.1_supplement.348.9" @default.
- W2292812467 hasPublicationYear "2010" @default.
- W2292812467 type Work @default.
- W2292812467 sameAs 2292812467 @default.
- W2292812467 citedByCount "0" @default.
- W2292812467 crossrefType "journal-article" @default.
- W2292812467 hasAuthorship W2292812467A5016216262 @default.
- W2292812467 hasAuthorship W2292812467A5028890075 @default.
- W2292812467 hasAuthorship W2292812467A5032644073 @default.
- W2292812467 hasAuthorship W2292812467A5066441448 @default.
- W2292812467 hasConcept C126322002 @default.
- W2292812467 hasConcept C134018914 @default.
- W2292812467 hasConcept C16005928 @default.
- W2292812467 hasConcept C185592680 @default.
- W2292812467 hasConcept C190283241 @default.
- W2292812467 hasConcept C2776914184 @default.
- W2292812467 hasConcept C2777363609 @default.
- W2292812467 hasConcept C3018555722 @default.
- W2292812467 hasConcept C502942594 @default.
- W2292812467 hasConcept C55493867 @default.
- W2292812467 hasConcept C71924100 @default.
- W2292812467 hasConceptScore W2292812467C126322002 @default.
- W2292812467 hasConceptScore W2292812467C134018914 @default.
- W2292812467 hasConceptScore W2292812467C16005928 @default.
- W2292812467 hasConceptScore W2292812467C185592680 @default.
- W2292812467 hasConceptScore W2292812467C190283241 @default.
- W2292812467 hasConceptScore W2292812467C2776914184 @default.
- W2292812467 hasConceptScore W2292812467C2777363609 @default.
- W2292812467 hasConceptScore W2292812467C3018555722 @default.
- W2292812467 hasConceptScore W2292812467C502942594 @default.
- W2292812467 hasConceptScore W2292812467C55493867 @default.
- W2292812467 hasConceptScore W2292812467C71924100 @default.
- W2292812467 hasFunder F4320306481 @default.
- W2292812467 hasFunder F4320332161 @default.
- W2292812467 hasIssue "S1" @default.
- W2292812467 hasLocation W22928124671 @default.
- W2292812467 hasOpenAccess W2292812467 @default.
- W2292812467 hasPrimaryLocation W22928124671 @default.
- W2292812467 hasRelatedWork W1976049453 @default.
- W2292812467 hasRelatedWork W1986621907 @default.
- W2292812467 hasRelatedWork W1997073923 @default.
- W2292812467 hasRelatedWork W2006066882 @default.
- W2292812467 hasRelatedWork W2015263989 @default.
- W2292812467 hasRelatedWork W2020954363 @default.
- W2292812467 hasRelatedWork W2027739385 @default.
- W2292812467 hasRelatedWork W2029498600 @default.
- W2292812467 hasRelatedWork W2035150802 @default.
- W2292812467 hasRelatedWork W2068093482 @default.
- W2292812467 hasRelatedWork W2072054714 @default.
- W2292812467 hasRelatedWork W2089654123 @default.
- W2292812467 hasRelatedWork W2103806424 @default.
- W2292812467 hasRelatedWork W2110722372 @default.
- W2292812467 hasRelatedWork W2125866073 @default.
- W2292812467 hasRelatedWork W2195166311 @default.
- W2292812467 hasRelatedWork W2297355201 @default.
- W2292812467 hasRelatedWork W2599138063 @default.
- W2292812467 hasRelatedWork W2902843681 @default.
- W2292812467 hasRelatedWork W2119282619 @default.
- W2292812467 hasVolume "24" @default.
- W2292812467 isParatext "false" @default.
- W2292812467 isRetracted "false" @default.
- W2292812467 magId "2292812467" @default.
- W2292812467 workType "article" @default.