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- W2292855799 abstract "In the past decade, the increasing incidence and distribution of paralytic shellfish poisoning (PSP) has become a global health problem. PSP is caused mainly by dinoflagellates in the genera Alexandrium, Pyrodinium and Gymnodinium. Although the chemical structures and toxicity of PSP toxins have been well elucidated, the multiple enzymes involved in the biosynthesis and metabolism of these toxins remain unknown. Understanding the pathways of dinoflagellate toxin production and breakdown is therefore fundamental in PSP research. The specific aim of this research was to develop a gel-based proteomic method to identify dinoflagellate proteins in order to distinguish between toxic and non-toxic strains and characterize enzyme(s) that are potentially involved in toxin metabolism. Alexandrium tamarense is a toxic dinoflagellate that produces PSP toxins and occurs in coastal areas of China. Both toxic and non-toxic strains of A. tamarense occur naturally and cannot be distinguished from one another using morphological features. The technique of gel-based proteomics was employed to unravel the proteome of toxic and non-toxic strains of A. tamarense. A potential biomarker for distinguishing between toxic and non-toxic strains, namely the AT-T1 protein, was discovered by the comparative proteomics method, and the AT-T1 protein was identified by mass spectrometry and N-terminal amino acid sequencing. Bioinformatics searches of this protein revealed no similar information in the database. Further characterization of this protein was performed by anti-AT-T1 monoclonal antibody probed assays developed in-house." @default.
- W2292855799 created "2016-06-24" @default.
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- W2292855799 date "2008-01-01" @default.
- W2292855799 modified "2023-09-27" @default.
- W2292855799 title "Investigation of dinoflagellate (Alexandrium species) proteins related to toxin biosynthesis : using a gel-based proteomic approach" @default.
- W2292855799 hasPublicationYear "2008" @default.
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