FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2292956239> ?p ?o ?g. }

• W2292956239 endingPage "656" @default.
• W2292956239 startingPage "644" @default.
• W2292956239 abstract "White matter hyperintensities accumulate with age and occur in patients with stroke, but their pathogenesis is poorly understood. We measured multiple magnetic resonance imaging biomarkers of tissue integrity in normal-appearing white matter and white matter hyperintensities in patients with mild stroke, to improve understanding of white matter hyperintensities origins. We classified white matter into white matter hyperintensities and normal-appearing white matter and measured fractional anisotropy, mean diffusivity, water content (T1-relaxation time) and blood–brain barrier leakage (signal enhancement slope from dynamic contrast-enhanced magnetic resonance imaging). We studied the effects of age, white matter hyperintensities burden (Fazekas score) and vascular risk factors on each biomarker, in normal-appearing white matter and white matter hyperintensities, and performed receiver-operator characteristic curve analysis. Amongst 204 patients (34.3–90.9 years), all biomarkers differed between normal-appearing white matter and white matter hyperintensities ( P < 0.001). In normal-appearing white matter and white matter hyperintensities, mean diffusivity and T1 increased with age ( P < 0.001), all biomarkers varied with white matter hyperintensities burden ( P < 0.001; P = 0.02 signal enhancement slope), but only signal enhancement slope increased with hypertension ( P = 0.028). Fractional anisotropy showed complex age-white matter hyperintensities-tissue interactions; enhancement slope showed white matter hyperintensities-tissue interactions. Mean diffusivity distinguished white matter hyperintensities from normal-appearing white matter best at all ages. Blood–brain barrier leakage increases with hypertension and white matter hyperintensities burden at all ages in normal-appearing white matter and white matter hyperintensities, whereas water mobility and content increase as tissue damage accrues, suggesting that blood–brain barrier leakage mediates small vessel disease-related brain damage." @default.
• W2292956239 created "2016-06-24" @default.
• W2292956239 creator A5001705802 @default.
• W2292956239 creator A5003194031 @default.
• W2292956239 creator A5005462505 @default.
• W2292956239 creator A5005477635 @default.
• W2292956239 creator A5028857433 @default.
• W2292956239 creator A5031686647 @default.
• W2292956239 creator A5034553962 @default.
• W2292956239 creator A5045827546 @default.
• W2292956239 creator A5050413666 @default.
• W2292956239 creator A5057530289 @default.
• W2292956239 creator A5074720746 @default.
• W2292956239 date "2016-07-21" @default.
• W2292956239 modified "2023-10-10" @default.
• W2292956239 title "Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease" @default.
• W2292956239 cites W1559360095 @default.
• W2292956239 cites W1827602057 @default.
• W2292956239 cites W1972609121 @default.
• W2292956239 cites W1973609741 @default.
• W2292956239 cites W1993512345 @default.
• W2292956239 cites W1997378060 @default.
• W2292956239 cites W1998016711 @default.
• W2292956239 cites W2002082105 @default.
• W2292956239 cites W2002986520 @default.
• W2292956239 cites W2008273493 @default.
• W2292956239 cites W2014614026 @default.
• W2292956239 cites W2014705540 @default.
• W2292956239 cites W2021883439 @default.
• W2292956239 cites W2032756463 @default.
• W2292956239 cites W2034275438 @default.
• W2292956239 cites W2037426713 @default.
• W2292956239 cites W2042712168 @default.
• W2292956239 cites W2043618136 @default.
• W2292956239 cites W2044381606 @default.
• W2292956239 cites W2060416311 @default.
• W2292956239 cites W2070486014 @default.
• W2292956239 cites W2072290762 @default.
• W2292956239 cites W2078103827 @default.
• W2292956239 cites W2082252904 @default.
• W2292956239 cites W2091931051 @default.
• W2292956239 cites W2092285090 @default.
• W2292956239 cites W2095287737 @default.
• W2292956239 cites W2097316769 @default.
• W2292956239 cites W2101376802 @default.
• W2292956239 cites W2102441526 @default.
• W2292956239 cites W2104931119 @default.
• W2292956239 cites W2106685029 @default.
• W2292956239 cites W2107956652 @default.
• W2292956239 cites W2108610949 @default.
• W2292956239 cites W2117359502 @default.
• W2292956239 cites W2117465877 @default.
• W2292956239 cites W2117844350 @default.
• W2292956239 cites W2122477279 @default.
• W2292956239 cites W2130766313 @default.
• W2292956239 cites W2131896620 @default.
• W2292956239 cites W2132874104 @default.
• W2292956239 cites W2138465150 @default.
• W2292956239 cites W2139158372 @default.
• W2292956239 cites W2140621953 @default.
• W2292956239 cites W2143060791 @default.
• W2292956239 cites W2144971762 @default.
• W2292956239 cites W2158742097 @default.
• W2292956239 cites W2159517512 @default.
• W2292956239 cites W2159899308 @default.
• W2292956239 cites W2168127946 @default.
• W2292956239 cites W4235770099 @default.
• W2292956239 doi "https://doi.org/10.1177/0271678x16635657" @default.
• W2292956239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5381455" @default.
• W2292956239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26933133" @default.
• W2292956239 hasPublicationYear "2016" @default.
• W2292956239 type Work @default.
• W2292956239 sameAs 2292956239 @default.
• W2292956239 citedByCount "121" @default.
• W2292956239 countsByYear W22929562392016 @default.
• W2292956239 countsByYear W22929562392017 @default.
• W2292956239 countsByYear W22929562392018 @default.
• W2292956239 countsByYear W22929562392019 @default.
• W2292956239 countsByYear W22929562392020 @default.
• W2292956239 countsByYear W22929562392021 @default.
• W2292956239 countsByYear W22929562392022 @default.
• W2292956239 countsByYear W22929562392023 @default.
• W2292956239 crossrefType "journal-article" @default.
• W2292956239 hasAuthorship W2292956239A5001705802 @default.
• W2292956239 hasAuthorship W2292956239A5003194031 @default.
• W2292956239 hasAuthorship W2292956239A5005462505 @default.
• W2292956239 hasAuthorship W2292956239A5005477635 @default.
• W2292956239 hasAuthorship W2292956239A5028857433 @default.
• W2292956239 hasAuthorship W2292956239A5031686647 @default.
• W2292956239 hasAuthorship W2292956239A5034553962 @default.
• W2292956239 hasAuthorship W2292956239A5045827546 @default.
• W2292956239 hasAuthorship W2292956239A5050413666 @default.
• W2292956239 hasAuthorship W2292956239A5057530289 @default.
• W2292956239 hasAuthorship W2292956239A5074720746 @default.
• W2292956239 hasBestOaLocation W22929562391 @default.
• W2292956239 hasConcept C126838900 @default.
• W2292956239 hasConcept C142724271 @default.
• W2292956239 hasConcept C143409427 @default.

• next