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• W2293007913 abstract "Abstract The Abdominal-B (Abd-B) gene, a member of the Drosophila bithorax complex, is required during development to specify the identity of parasegments 10– 14. Based on genetic studies, Casanova, J., Sánchez-Herrero, E. and Morata, G. (1986) Cell 47, 627-636, proposed that the Abd-B gene consists of two distinct elements that provide a morphogenetic (m) function in PS 10-13 and a regulatory (r) function in PS 14, where it represses m function. Here we present molecular confirmation of this genetic model. . Using specific antibodies, we show that the 55x103Mr and 30x103MrAbd-B proteins, predicted by cDNA analysis, are indeed present in PS 10-13 and PS 14, respectively. We also examine Abd-B mRNA and protein expression patterns in embryos mutant for either the m or r function. These data allow us to unambiguously assign m function to the 55x103Mr protein and r function to the 30x103Mr protein. Furthermore, as postulated by the model, transcription of the mRNA encoding the m protein is derepressed in PS 14 in the absence of r function. We have also studied the effect of mutations mapping in the infra-abdominal (iab) region located downstream of the Abd-B gene. Genetic studies suggest that the iab region contains crv-acting regulatory elements controlling Abd-B expression in PS 10-12. We present molecular evidence for the presence of downstream crs-regulatory elements by analyzing Abd-B mRNA and protein patterns in iab-6 and iab-7 embryos. Our analysis reveals the presence of parasegment and cell-specific regulatory elements of the Abd-B gene within each iab region. The Abd-B gene may provide a model for the understanding of similarly complex homeotic genes in higher organisms." @default.
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• W2293007913 date "1991-02-01" @default.
• W2293007913 modified "2023-10-09" @default.
• W2293007913 title "Molecular definition of the morphogenetic and regulatory functions and the <i>cis</i>-regulatory elements of the <i>Drosophila Abd-B</i> homeotic gene" @default.
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• W2293007913 doi "https://doi.org/10.1242/dev.111.2.393" @default.
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