FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2293072912> ?p ?o ?g. }

• W2293072912 endingPage "967" @default.
• W2293072912 startingPage "956" @default.
• W2293072912 abstract "The interleukin-2 (IL-2) receptor gamma chain is indispensable for IL-2- , IL-4-, IL-7-, IL-9-, and IL-15-mediated signaling. Mutations of the human gamma chain cause the X-linked severe combined immunodeficiency (XSCID), showing that T and natural killer cells absolutely require the gamma chain for their development in humans. To elucidate the roles of the gamma chain in hematopoiesis, we have generated mice, by gene targeting, that express a form of the gamma chain lacking the cytoplasmic region. Male mice carrying the truncated gamma-chain mutant, which mimics mutations in patients with XSCID, showed a decrease in the number of lymphocytes and an increase in monocytes; the number of T cells was profoundly reduced and no natural killer cells were detected, which is similar to the characteristic of human XSCID. Unlike human XSCID, the levels of B cells were also reduced. In spite of the severe decrease in CD45R+/sIgM+ B cells, the level of IgM in serum of the 8-week-old mutant mice was higher than that of control littermates. Interestingly, the stem cell population with surface phenotypes of CD34, c-kit, and Sca-1 was significantly increased. Furthermore, the colony-forming assay showed that the mutant mice had 15-fold higher numbers of hematopoietic progenitor cells in the spleen as compared with that of controls. These results indicate that functional loss of the gamma chain causes significant effects on the immunological system in mice." @default.
• W2293072912 created "2016-06-24" @default.
• W2293072912 creator A5001371042 @default.
• W2293072912 creator A5003840117 @default.
• W2293072912 creator A5022962909 @default.
• W2293072912 creator A5033349864 @default.
• W2293072912 creator A5035156230 @default.
• W2293072912 creator A5040582134 @default.
• W2293072912 creator A5054636847 @default.
• W2293072912 creator A5064812624 @default.
• W2293072912 creator A5066601804 @default.
• W2293072912 creator A5068535859 @default.
• W2293072912 creator A5080994037 @default.
• W2293072912 creator A5087838405 @default.
• W2293072912 date "1996-02-01" @default.
• W2293072912 modified "2023-10-14" @default.
• W2293072912 title "Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain" @default.
• W2293072912 doi "https://doi.org/10.1182/blood.v87.3.956.bloodjournal873956" @default.
• W2293072912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8562967" @default.
• W2293072912 hasPublicationYear "1996" @default.
• W2293072912 type Work @default.
• W2293072912 sameAs 2293072912 @default.
• W2293072912 citedByCount "255" @default.
• W2293072912 countsByYear W22930729122012 @default.
• W2293072912 countsByYear W22930729122013 @default.
• W2293072912 countsByYear W22930729122014 @default.
• W2293072912 countsByYear W22930729122015 @default.
• W2293072912 countsByYear W22930729122016 @default.
• W2293072912 countsByYear W22930729122017 @default.
• W2293072912 countsByYear W22930729122018 @default.
• W2293072912 countsByYear W22930729122019 @default.
• W2293072912 countsByYear W22930729122020 @default.
• W2293072912 countsByYear W22930729122021 @default.
• W2293072912 countsByYear W22930729122022 @default.
• W2293072912 countsByYear W22930729122023 @default.
• W2293072912 crossrefType "journal-article" @default.
• W2293072912 hasAuthorship W2293072912A5001371042 @default.
• W2293072912 hasAuthorship W2293072912A5003840117 @default.
• W2293072912 hasAuthorship W2293072912A5022962909 @default.
• W2293072912 hasAuthorship W2293072912A5033349864 @default.
• W2293072912 hasAuthorship W2293072912A5035156230 @default.
• W2293072912 hasAuthorship W2293072912A5040582134 @default.
• W2293072912 hasAuthorship W2293072912A5054636847 @default.
• W2293072912 hasAuthorship W2293072912A5064812624 @default.
• W2293072912 hasAuthorship W2293072912A5066601804 @default.
• W2293072912 hasAuthorship W2293072912A5068535859 @default.
• W2293072912 hasAuthorship W2293072912A5080994037 @default.
• W2293072912 hasAuthorship W2293072912A5087838405 @default.
• W2293072912 hasBestOaLocation W22930729121 @default.
• W2293072912 hasConcept C104317684 @default.
• W2293072912 hasConcept C109159458 @default.
• W2293072912 hasConcept C143065580 @default.
• W2293072912 hasConcept C153911025 @default.
• W2293072912 hasConcept C187316574 @default.
• W2293072912 hasConcept C203014093 @default.
• W2293072912 hasConcept C2778690821 @default.
• W2293072912 hasConcept C2779468541 @default.
• W2293072912 hasConcept C2780931953 @default.
• W2293072912 hasConcept C28328180 @default.
• W2293072912 hasConcept C2908647359 @default.
• W2293072912 hasConcept C54355233 @default.
• W2293072912 hasConcept C71924100 @default.
• W2293072912 hasConcept C74172505 @default.
• W2293072912 hasConcept C86803240 @default.
• W2293072912 hasConcept C8891405 @default.
• W2293072912 hasConcept C95444343 @default.
• W2293072912 hasConcept C98119934 @default.
• W2293072912 hasConcept C98654944 @default.
• W2293072912 hasConcept C99454951 @default.
• W2293072912 hasConceptScore W2293072912C104317684 @default.
• W2293072912 hasConceptScore W2293072912C109159458 @default.
• W2293072912 hasConceptScore W2293072912C143065580 @default.
• W2293072912 hasConceptScore W2293072912C153911025 @default.
• W2293072912 hasConceptScore W2293072912C187316574 @default.
• W2293072912 hasConceptScore W2293072912C203014093 @default.
• W2293072912 hasConceptScore W2293072912C2778690821 @default.
• W2293072912 hasConceptScore W2293072912C2779468541 @default.
• W2293072912 hasConceptScore W2293072912C2780931953 @default.
• W2293072912 hasConceptScore W2293072912C28328180 @default.
• W2293072912 hasConceptScore W2293072912C2908647359 @default.
• W2293072912 hasConceptScore W2293072912C54355233 @default.
• W2293072912 hasConceptScore W2293072912C71924100 @default.
• W2293072912 hasConceptScore W2293072912C74172505 @default.
• W2293072912 hasConceptScore W2293072912C86803240 @default.
• W2293072912 hasConceptScore W2293072912C8891405 @default.
• W2293072912 hasConceptScore W2293072912C95444343 @default.
• W2293072912 hasConceptScore W2293072912C98119934 @default.
• W2293072912 hasConceptScore W2293072912C98654944 @default.
• W2293072912 hasConceptScore W2293072912C99454951 @default.
• W2293072912 hasIssue "3" @default.
• W2293072912 hasLocation W22930729121 @default.
• W2293072912 hasOpenAccess W2293072912 @default.
• W2293072912 hasPrimaryLocation W22930729121 @default.
• W2293072912 hasRelatedWork W2021591120 @default.
• W2293072912 hasRelatedWork W2036107469 @default.
• W2293072912 hasRelatedWork W2081358646 @default.
• W2293072912 hasRelatedWork W2081537178 @default.
• W2293072912 hasRelatedWork W2119511363 @default.

• next