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- W2293109110 abstract "ABSTRACT: Hemolysins of Leptospira interragans have been shown to be the virulence factor in the pathogenesis of leptospirosis and 10 potential hemolysin genes were charecterized by genomic annotation of L.interrogans serovar. Lai strain 5660l. In the present study, the LA0202 gene supposed to encode one of the new potential hemolysin was cloned and the protein encoded was purified. The purified protein was shown to have highly hemolytic activity as demonstrated on the sheep blood agar plate. It was also confirmed that the LA0202 protein-mediated hemolysis on sheep erythrocytes was osmotically protected by PEG6000. Mean while, this protein could induce pore form at ion on sheep erythrocytes and cause damages on the membrane of hum an L-02 liver cells. In addition, it could induce apoptosis of human L-02 liver cells after treatment of cells with this protein for 24 hours. It is evident that LA0202 protein acting as a pore-forming hemolysin can induce cytotoxic damage on mammalian cells." @default.
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- W2293109110 date "2009-09-20" @default.
- W2293109110 modified "2023-09-23" @default.
- W2293109110 title "A novel pore-forming Hemolysin Protein in Leptospira species" @default.
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