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• W2293109396 abstract "Thesis (Ph.D.)--Georgetown University, 2008.; Includes bibliographical references. Genistein, the most abundant isoflavonoid found in soy and other leguminous plants such as lentils, has cancer growth modulating effects that vary based on its concentration. It is unclear which particular concentrations of genistein have a cancer promoting or cancer inhibiting effect. The mechanism for enhanced cancer cell proliferation by genistein is also unknown. One molecular target of genistein is telomerase. Telomerase imparts endless replicative potential to cancer cells by facilitating proliferation and survival through the alteration of growth factors and apoptotic proteins. Having previously determined that pharmacological concentrations of genistein repress telomerase activity and prostate cancer cell growth, we examined the effect of physiologically achievable concentrations of genistein on telomerase activity and cancer cell proliferation. We found that physiologically achievable concentrations of genistein enhance telomerase activity and human prostate cancer cell growth. Signal transducers and activators of transcription 3 (STAT3) activation and increased STAT3 binding to the telomerase reverse transcriptase (TERT) promoter by physiological concentrations of genistein were identified as the mechanism for enhanced telomerase activity in human prostate cancer cells.; The mechanism for genistein-induced activation of STAT3 was then determined. A physiological concentration of genistein activated signaling proteins upstream of STAT3 including JAK2, Akt, Src, and MAPK p44/42 in human prostate cancer cells. Specific shRNA inhibition of these signaling proteins in stable STAT3 reporter prostate cancer cells reduced STAT3 reporter activity and cancer cell proliferation. Genistein treatment of cells with the signaling proteins inhibited did not increase STAT3 reporter activity and cancer cell proliferation to the level observed in genistein treated control cells, indicating that JAK2, Akt, Src, and MAPK p44/42 are necessary for genistein-induced activation of STAT3. The data collectively suggests that physiologically achievable concentrations of genistein enhance cancer cell proliferation by increasing telomerase activity via STAT3 activation mediated by upstream signaling proteins. The result that physiological concentrations of genistein promote prostate cancer cell growth indicates that prudence should be exercised when genistein is considered for chemotherapeutic purposes as unfavorable effects in individuals with prostate cancer is possible." @default.
• W2293109396 created "2016-06-24" @default.
• W2293109396 creator A5068180050 @default.
• W2293109396 date "2008-01-01" @default.
• W2293109396 modified "2023-09-27" @default.
• W2293109396 title "Regulation of telomerase by genistein in human prostate cancer cells" @default.
• W2293109396 cites W1501603134 @default.
• W2293109396 cites W1558123369 @default.
• W2293109396 cites W1563929113 @default.
• W2293109396 cites W1574658543 @default.
• W2293109396 cites W1584223654 @default.
• W2293109396 cites W1603925779 @default.
• W2293109396 cites W1612842202 @default.
• W2293109396 cites W1656644300 @default.
• W2293109396 cites W1676540962 @default.
• W2293109396 cites W1749733472 @default.
• W2293109396 cites W1761773172 @default.
• W2293109396 cites W1772982693 @default.
• W2293109396 cites W1789961596 @default.
• W2293109396 cites W1821858011 @default.
• W2293109396 cites W1845534504 @default.
• W2293109396 cites W1858959628 @default.
• W2293109396 cites W1865050205 @default.
• W2293109396 cites W1892268352 @default.
• W2293109396 cites W1901011363 @default.
• W2293109396 cites W1903353148 @default.
• W2293109396 cites W1907119490 @default.
• W2293109396 cites W1908195810 @default.
• W2293109396 cites W1917630072 @default.
• W2293109396 cites W1932287526 @default.
• W2293109396 cites W1945654865 @default.
• W2293109396 cites W1946359192 @default.
• W2293109396 cites W1958617459 @default.
• W2293109396 cites W1965589616 @default.
• W2293109396 cites W1966296779 @default.
• W2293109396 cites W1969241521 @default.
• W2293109396 cites W1970878541 @default.
• W2293109396 cites W1971860231 @default.
• W2293109396 cites W1973686522 @default.
• W2293109396 cites W1974305754 @default.
• W2293109396 cites W1977159265 @default.
• W2293109396 cites W1977841967 @default.
• W2293109396 cites W1979785616 @default.
• W2293109396 cites W1984374449 @default.
• W2293109396 cites W1986394211 @default.
• W2293109396 cites W1987947780 @default.
• W2293109396 cites W1988719795 @default.
• W2293109396 cites W1989345460 @default.
• W2293109396 cites W1989561420 @default.
• W2293109396 cites W1990327942 @default.
• W2293109396 cites W1991498850 @default.
• W2293109396 cites W1993059245 @default.
• W2293109396 cites W1993520606 @default.
• W2293109396 cites W1994048261 @default.
• W2293109396 cites W1994159353 @default.
• W2293109396 cites W1994245797 @default.
• W2293109396 cites W1994717489 @default.
• W2293109396 cites W1997732940 @default.
• W2293109396 cites W1998336488 @default.
• W2293109396 cites W1998732486 @default.
• W2293109396 cites W2000971601 @default.
• W2293109396 cites W2001297877 @default.
• W2293109396 cites W2001566280 @default.
• W2293109396 cites W2002205097 @default.
• W2293109396 cites W2002883144 @default.
• W2293109396 cites W2003851518 @default.
• W2293109396 cites W2006382528 @default.
• W2293109396 cites W2008313660 @default.
• W2293109396 cites W2008877467 @default.
• W2293109396 cites W2009582320 @default.
• W2293109396 cites W2009819537 @default.
• W2293109396 cites W2011120797 @default.
• W2293109396 cites W2014022113 @default.
• W2293109396 cites W2014482493 @default.
• W2293109396 cites W2014676294 @default.
• W2293109396 cites W2015047103 @default.
• W2293109396 cites W2017585917 @default.
• W2293109396 cites W2017752436 @default.
• W2293109396 cites W2018510674 @default.
• W2293109396 cites W2018569669 @default.
• W2293109396 cites W2018596412 @default.
• W2293109396 cites W2019498433 @default.
• W2293109396 cites W2021080217 @default.
• W2293109396 cites W2021780953 @default.
• W2293109396 cites W2022215206 @default.
• W2293109396 cites W2022301159 @default.
• W2293109396 cites W2022507419 @default.
• W2293109396 cites W2023578203 @default.
• W2293109396 cites W2024282024 @default.
• W2293109396 cites W2024434952 @default.
• W2293109396 cites W2024787154 @default.
• W2293109396 cites W2025791374 @default.
• W2293109396 cites W2026159928 @default.
• W2293109396 cites W2026897480 @default.
• W2293109396 cites W2027899150 @default.
• W2293109396 cites W2028848985 @default.
• W2293109396 cites W2029735450 @default.
• W2293109396 cites W2029778736 @default.
• W2293109396 cites W2032303692 @default.
• W2293109396 cites W2032696050 @default.

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