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- W2293213886 abstract "Abstract Increased quantities of colony-stimulating factor (CSF), capable of stimulating the in vitro growth of colonies of granulocytes and mononuclear cells from murine marrow was present in the plasma of mice injected with Salmonella typhosa endotoxin. Increased CSF occurred within 30 minutes after injection as the animals became neutropenic. Peak activity of approximately 600 per cent of control value occurred between 2 to 8 hours following the injection of either 5.0 μg or 50.0 μg of endotoxin. Peak activity occurred between 2 to 4 hours after 5.0 μg and then declined to normal levels by 24 hours. After 50.0 μg, peak activity occurred between 4 to 8 hours and remained slightly above normal after 24 hours. The addition of endotoxin directly to unstimulated cultures or to cultures stimulated with conditioned medium did not enhance colony growth. Concentrations of endotoxin less than 0.01 μg had no effect, while concentrations of 0.1 μg or more inhibited colony formation. Incubating endotoxin with normal mouse plasma (NMP) prior to adding it to the cultures did not enhance colony growth. Thus, postendotoxin plasma has marked stimulatory effects on granulocytopoiesis in vitro, which is not due to endotoxin per se or to its interaction with plasma. The relationship of increased CSF to neutropenia suggests that CSF is a neutropoietin and perhaps a physiologic regulator of granulopoiesis." @default.
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- W2293213886 date "1972-06-01" @default.
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- W2293213886 title "Effect of endotoxin and postendotoxin plasma on in vitro granulopoiesis." @default.
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