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• W2293379251 endingPage "797" @default.
• W2293379251 startingPage "787" @default.
• W2293379251 abstract "Heparin-induced thrombocytopenia (HIT) is a drug-mediated, prothrombotic disorder caused by immunization against platelet factor 4 (PF4) after complex formation with heparin or other polyanions. A subset of anti-PF4/heparin antibodies are capable of intravascular platelet activation by cross-linking Fcgamma receptor IIA leading to platelet count decrease and/or thrombosis. HIT can be potentially associated with devastating complications such as life-threatening thrombosis making it one of the most serious adverse drug reactions. Diagnosis of HIT based on clinical information is often difficult.This review highlights the pathophysiology of HIT, emphasizing characteristic clinical features and the role of laboratory assays in the diagnosis of HIT. In addition, a summary of current therapeutic options for patients with HIT will be provided.A combination of clinical pretest scoring system and laboratory investigation is usually necessary to diagnose HIT. If HIT is strongly suspected, all sources of heparin must be stopped and an alternative non-heparin anticoagulant should be started to prevent new thromboembolic complications. However, heparin alternative anticoagulants bear a considerable bleeding risk, especially if given to patients with thrombocytopenia due to other reasons than HIT. A better understanding of clinical and laboratory features of HIT may help developing strategies to avoid complications induced by this serious adverse reaction against heparin." @default.
• W2293379251 created "2016-06-24" @default.
• W2293379251 creator A5066897101 @default.
• W2293379251 date "2016-04-07" @default.
• W2293379251 modified "2023-09-25" @default.
• W2293379251 title "An update on heparin-induced thrombocytopenia: diagnosis and management" @default.
• W2293379251 cites W108425301 @default.
• W2293379251 cites W124032993 @default.
• W2293379251 cites W1504930481 @default.
• W2293379251 cites W1526295626 @default.
• W2293379251 cites W1580172015 @default.
• W2293379251 cites W1590681435 @default.
• W2293379251 cites W1660256439 @default.
• W2293379251 cites W1741771043 @default.
• W2293379251 cites W1821012649 @default.
• W2293379251 cites W1839957198 @default.
• W2293379251 cites W193975376 @default.
• W2293379251 cites W1952443482 @default.
• W2293379251 cites W1966909314 @default.
• W2293379251 cites W1967056801 @default.
• W2293379251 cites W1967115159 @default.
• W2293379251 cites W1972070319 @default.
• W2293379251 cites W1973684446 @default.
• W2293379251 cites W1978093544 @default.
• W2293379251 cites W1978844926 @default.
• W2293379251 cites W1981556754 @default.
• W2293379251 cites W1982536750 @default.
• W2293379251 cites W1987924191 @default.
• W2293379251 cites W1988022045 @default.
• W2293379251 cites W1988878030 @default.
• W2293379251 cites W1993403390 @default.
• W2293379251 cites W1993511910 @default.
• W2293379251 cites W1994517658 @default.
• W2293379251 cites W2001894797 @default.
• W2293379251 cites W2003618825 @default.
• W2293379251 cites W2004998033 @default.
• W2293379251 cites W2005336533 @default.
• W2293379251 cites W2007781248 @default.
• W2293379251 cites W2007933904 @default.
• W2293379251 cites W2012245768 @default.
• W2293379251 cites W2012314462 @default.
• W2293379251 cites W2018487385 @default.
• W2293379251 cites W2018716443 @default.
• W2293379251 cites W2019138823 @default.
• W2293379251 cites W2019668407 @default.
• W2293379251 cites W2020839629 @default.
• W2293379251 cites W2023958942 @default.
• W2293379251 cites W2024305286 @default.
• W2293379251 cites W2028622537 @default.
• W2293379251 cites W2029430078 @default.
• W2293379251 cites W2031454492 @default.
• W2293379251 cites W2040918827 @default.
• W2293379251 cites W2040920500 @default.
• W2293379251 cites W2043674837 @default.
• W2293379251 cites W2044969493 @default.
• W2293379251 cites W2050059958 @default.
• W2293379251 cites W2053593414 @default.
• W2293379251 cites W2058608811 @default.
• W2293379251 cites W2058690387 @default.
• W2293379251 cites W2063768171 @default.
• W2293379251 cites W2064070223 @default.
• W2293379251 cites W2064355824 @default.
• W2293379251 cites W2066510606 @default.
• W2293379251 cites W2069317152 @default.
• W2293379251 cites W2070063154 @default.
• W2293379251 cites W2070650376 @default.
• W2293379251 cites W2071961135 @default.
• W2293379251 cites W2076599358 @default.
• W2293379251 cites W2078875832 @default.
• W2293379251 cites W2093698397 @default.
• W2293379251 cites W2097986908 @default.
• W2293379251 cites W2102517652 @default.
• W2293379251 cites W2102855173 @default.
• W2293379251 cites W2106373645 @default.
• W2293379251 cites W2107217734 @default.
• W2293379251 cites W2108727087 @default.
• W2293379251 cites W2112564023 @default.
• W2293379251 cites W2118049862 @default.
• W2293379251 cites W2124667094 @default.
• W2293379251 cites W2133229778 @default.
• W2293379251 cites W2140112885 @default.
• W2293379251 cites W2140436541 @default.
• W2293379251 cites W2150922204 @default.
• W2293379251 cites W2161607361 @default.
• W2293379251 cites W2165313346 @default.
• W2293379251 cites W2170138525 @default.
• W2293379251 cites W2237091553 @default.
• W2293379251 cites W2317506800 @default.
• W2293379251 cites W2333983635 @default.
• W2293379251 cites W2418821229 @default.
• W2293379251 cites W2911131326 @default.
• W2293379251 cites W36050078 @default.
• W2293379251 cites W77107658 @default.
• W2293379251 cites W79694754 @default.
• W2293379251 cites W8062481 @default.
• W2293379251 cites W2162989731 @default.
• W2293379251 doi "https://doi.org/10.1517/14740338.2016.1165667" @default.
• W2293379251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26966871" @default.

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