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• W2293461567 abstract "Immune complex (IC) deposition in the glomerular basement membrane (GBM) is a key early pathogenic event in lupus nephritis (LN). The clarification of the mechanisms behind IC deposition will enable targeted therapy in the future. Circulating cell-derived microparticles (MPs) have been proposed as major sources of extracellular autoantigens and ICs and triggers of autoimmunity in LN. The overabundance of galectin-3-binding protein (G3BP) along with immunoglobulins and a few other proteins specifically distinguish circulating MPs in patients with systemic lupus erythematosus (SLE), and this is most pronounced in patients with active LN. G3BP co-localizes with deposited ICs in renal biopsies from LN patients supporting a significant presence of MPs in the IC deposits. G3BP binds strongly to glomerular basement membrane proteins and integrins. Accordingly, MP surface proteins, especially G3BP, may be essential for the deposition of ICs in kidneys and thus for the ensuing formation of MP-derived electron dense structures in the GBM, and immune activation in LN. This review focuses on the notion of targeting surface molecules on MPs as an entirely novel treatment strategy in LN. By targeting MPs, a double hit may be achieved by attenuating both the autoantigenic fueling of immune complexes and the triggering of the adaptive immune system. Thereby, early pathogenic events may be blocked in contrast to current treatment strategies that primarily target and modulate later events in the cellular and humoral immune response." @default.
• W2293461567 created "2016-06-24" @default.
• W2293461567 creator A5014147944 @default.
• W2293461567 creator A5033697331 @default.
• W2293461567 creator A5053356441 @default.
• W2293461567 creator A5086180632 @default.
• W2293461567 date "2016-07-01" @default.
• W2293461567 modified "2023-09-27" @default.
• W2293461567 title "“Kill” the messenger: Targeting of cell-derived microparticles in lupus nephritis" @default.
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• W2293461567 doi "https://doi.org/10.1016/j.autrev.2016.03.009" @default.
• W2293461567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26970484" @default.
• W2293461567 hasPublicationYear "2016" @default.
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