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• W2293619782 abstract "We investigated the efficacy of optogenetic inhibition at presynaptic terminals using halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed activation of both archaerhodopsin and halorhodpsin at presynaptic terminals attenuated evoked release. However, sustained archaerhodopsin activation was paradoxically associated with increased spontaneous release. Activation of chloride-conducting channelrhodopsins triggered neurotransmitter release upon light onset. Thus, the biophysical properties of presynaptic terminals dictate unique boundary conditions for optogenetic manipulation." @default.
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• W2293619782 date "2016-03-07" @default.
• W2293619782 modified "2023-10-17" @default.
• W2293619782 title "Biophysical constraints of optogenetic inhibition at presynaptic terminals" @default.
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• W2293619782 doi "https://doi.org/10.1038/nn.4266" @default.
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