FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2293635209> ?p ?o ?g. }

• W2293635209 endingPage "30" @default.
• W2293635209 startingPage "16" @default.
• W2293635209 abstract "Aging results in a decline of physiological functions and in reduced repair capacities, in part due to impaired regenerative power of stem cells, influenced by the systemic environment. In particular osteogenic differentiation capacity (ODC) of mesenchymal stem cells (MSCs) has been shown to decrease with age, thereby contributing to reduced bone formation and an increased fracture risk. Searching for systemic factors that might contribute to this age related decline of regenerative capacity led us to investigate plasma-derived extracellular vesicles (EVs). EVs of the elderly were found to inhibit osteogenesis compared to those of young individuals. By analyzing the differences in the vesicular content Galectin-3 was shown to be reduced in elderly-derived vesicles. While overexpression of Galectin-3 resulted in an enhanced ODC of MSCs, siRNA against Galectin-3 reduced osteogenesis. Modulation of intravesicular Galectin-3 levels correlated with an altered osteo-inductive potential indicating that vesicular Galectin-3 contributes to the biological response of MSCs to EVs. By site-directed mutagenesis we identified a phosphorylation-site on Galectin-3 mediating this effect. Finally, we showed that cell penetrating peptides comprising this phosphorylation-site are sufficient to increase ODC in MSCs. Therefore, we suggest that decrease of Galectin-3 in the plasma of elderly contributes to the age-related loss of ODC." @default.
• W2293635209 created "2016-06-24" @default.
• W2293635209 creator A5000192984 @default.
• W2293635209 creator A5011414289 @default.
• W2293635209 creator A5020312784 @default.
• W2293635209 creator A5022974644 @default.
• W2293635209 creator A5023342659 @default.
• W2293635209 creator A5023370153 @default.
• W2293635209 creator A5025576392 @default.
• W2293635209 creator A5028613853 @default.
• W2293635209 creator A5029549917 @default.
• W2293635209 creator A5030094052 @default.
• W2293635209 creator A5030343627 @default.
• W2293635209 creator A5054673819 @default.
• W2293635209 creator A5058786740 @default.
• W2293635209 creator A5068178323 @default.
• W2293635209 date "2016-01-09" @default.
• W2293635209 modified "2023-09-26" @default.
• W2293635209 title "Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles" @default.
• W2293635209 cites W1832220924 @default.
• W2293635209 cites W1973242875 @default.
• W2293635209 cites W1974218300 @default.
• W2293635209 cites W1988027744 @default.
• W2293635209 cites W2025550161 @default.
• W2293635209 cites W2025690176 @default.
• W2293635209 cites W2054803188 @default.
• W2293635209 cites W2076491580 @default.
• W2293635209 cites W2077510301 @default.
• W2293635209 cites W2083308065 @default.
• W2293635209 cites W2085435711 @default.
• W2293635209 cites W2087578260 @default.
• W2293635209 cites W2088107344 @default.
• W2293635209 cites W2111019629 @default.
• W2293635209 cites W2128384671 @default.
• W2293635209 cites W2138896629 @default.
• W2293635209 cites W2141138739 @default.
• W2293635209 cites W2262141841 @default.
• W2293635209 doi "https://doi.org/10.18632/aging.100865" @default.
• W2293635209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4931861" @default.
• W2293635209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27280770" @default.
• W2293635209 hasPublicationYear "2016" @default.
• W2293635209 type Work @default.
• W2293635209 sameAs 2293635209 @default.
• W2293635209 citedByCount "67" @default.
• W2293635209 countsByYear W22936352092016 @default.
• W2293635209 countsByYear W22936352092017 @default.
• W2293635209 countsByYear W22936352092018 @default.
• W2293635209 countsByYear W22936352092019 @default.
• W2293635209 countsByYear W22936352092020 @default.
• W2293635209 countsByYear W22936352092021 @default.
• W2293635209 countsByYear W22936352092022 @default.
• W2293635209 countsByYear W22936352092023 @default.
• W2293635209 crossrefType "journal-article" @default.
• W2293635209 hasAuthorship W2293635209A5000192984 @default.
• W2293635209 hasAuthorship W2293635209A5011414289 @default.
• W2293635209 hasAuthorship W2293635209A5020312784 @default.
• W2293635209 hasAuthorship W2293635209A5022974644 @default.
• W2293635209 hasAuthorship W2293635209A5023342659 @default.
• W2293635209 hasAuthorship W2293635209A5023370153 @default.
• W2293635209 hasAuthorship W2293635209A5025576392 @default.
• W2293635209 hasAuthorship W2293635209A5028613853 @default.
• W2293635209 hasAuthorship W2293635209A5029549917 @default.
• W2293635209 hasAuthorship W2293635209A5030094052 @default.
• W2293635209 hasAuthorship W2293635209A5030343627 @default.
• W2293635209 hasAuthorship W2293635209A5054673819 @default.
• W2293635209 hasAuthorship W2293635209A5058786740 @default.
• W2293635209 hasAuthorship W2293635209A5068178323 @default.
• W2293635209 hasBestOaLocation W22936352091 @default.
• W2293635209 hasConcept C104317684 @default.
• W2293635209 hasConcept C10854531 @default.
• W2293635209 hasConcept C11960822 @default.
• W2293635209 hasConcept C130316041 @default.
• W2293635209 hasConcept C145059251 @default.
• W2293635209 hasConcept C185592680 @default.
• W2293635209 hasConcept C198826908 @default.
• W2293635209 hasConcept C203014093 @default.
• W2293635209 hasConcept C20518536 @default.
• W2293635209 hasConcept C2776336362 @default.
• W2293635209 hasConcept C28328180 @default.
• W2293635209 hasConcept C28406088 @default.
• W2293635209 hasConcept C2908689518 @default.
• W2293635209 hasConcept C2992929900 @default.
• W2293635209 hasConcept C41625074 @default.
• W2293635209 hasConcept C55493867 @default.
• W2293635209 hasConcept C86803240 @default.
• W2293635209 hasConcept C95444343 @default.
• W2293635209 hasConceptScore W2293635209C104317684 @default.
• W2293635209 hasConceptScore W2293635209C10854531 @default.
• W2293635209 hasConceptScore W2293635209C11960822 @default.
• W2293635209 hasConceptScore W2293635209C130316041 @default.
• W2293635209 hasConceptScore W2293635209C145059251 @default.
• W2293635209 hasConceptScore W2293635209C185592680 @default.
• W2293635209 hasConceptScore W2293635209C198826908 @default.
• W2293635209 hasConceptScore W2293635209C203014093 @default.
• W2293635209 hasConceptScore W2293635209C20518536 @default.
• W2293635209 hasConceptScore W2293635209C2776336362 @default.
• W2293635209 hasConceptScore W2293635209C28328180 @default.
• W2293635209 hasConceptScore W2293635209C28406088 @default.

• next