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- W2293676206 endingPage "484" @default.
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- W2293676206 abstract "Personalized medicine is the science of individualized prevention and therapy. In the last decade, advances in high-throughput approaches allowed the development of proteomic and metabolomic studies in evaluating the association of genetic and phenotypic variability with disease sensitivity and analgesic response. These considerations have more value in case of multiple sclerosis (MuS), a multifactorial disease with high heterogeneity in clinical course and treatment response. In this review, we reported and updated about proteomic and metabolomic studies for the research of new candidate biomarkers in MuS, and difficulties in their clinical applications. We focused especially on the description of both omics approaches that, once integrated, may synergically describe pathophysiology conditions. To prove this assumption, we rebuilt interaction between proteins and metabolites described in the literature as potential biomarkers for MuS, and a pathway analysis of these molecules was performed. The result of such speculation demonstrated a strong convergence of proteomic and metabolomic results in this field, showing also a poorness of available tools for incorporating omics approaches. In conclusion, the integration of Metabolomics and Proteomics may allow a more complete characterization of such a heterogeneous disease, providing further insights into personalized healthcare." @default.
- W2293676206 created "2016-06-24" @default.
- W2293676206 creator A5000615064 @default.
- W2293676206 creator A5028252016 @default.
- W2293676206 creator A5037946109 @default.
- W2293676206 creator A5054208280 @default.
- W2293676206 creator A5069967189 @default.
- W2293676206 creator A5091634152 @default.
- W2293676206 date "2016-03-11" @default.
- W2293676206 modified "2023-09-26" @default.
- W2293676206 title "Integration of metabolomics and proteomics in multiple sclerosis: From biomarkers discovery to personalized medicine" @default.
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