FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2293676503> ?p ?o ?g. }

• W2293676503 abstract "Several epidemiological and laboratory studies have evidenced the fact that atmospheric particulate matter (PM) increases the risk of respiratory morbidity. It is well known that the smallest fraction of PM (PM1 - particulate matter having a diameter below 1 μm) penetrates the deepest into the airways. The ratio of the different size fractions in PM is highly variable, but in industrial areas PM1 can be significant. Despite these facts, the health effects of PM1 have been poorly investigated and air quality standards are based on PM10 and PM2.5 (PM having diameters below 10 μm and 2.5 μm, respectively) concentrations. Therefore, this study aimed at determining whether exposure to ambient PM1 at a near alert threshold level for PM10 has respiratory consequences in rats.Rats were either exposed for 6 weeks to 100 μg/m(3) (alert threshold level for PM10 in Hungary) urban submicron aerosol, or were kept in room air. End-expiratory lung volume, airway resistance (Raw) and respiratory tissue mechanics were measured. Respiratory mechanics were measured under baseline conditions and following intravenous methacholine challenges to characterize the development of airway hyperresponsiveness (AH). Bronchoalveolar lavage fluid (BALF) was analyzed and lung histology was performed.No significant differences were detected in lung volume and mechanical parameters at baseline. However, the exposed rats exhibited significantly greater MCh-induced responses in Raw, demonstrating the progression of AH. The associated bronchial inflammation was evidenced by the accumulation of inflammatory cells in BALF and by lung histology.Our findings suggest that exposure to concentrated ambient PM1 (mass concentration at the threshold level for PM10) leads to the development of mild respiratory symptoms in healthy adult rats, which may suggest a need for the reconsideration of threshold limits for airborne PM1." @default.
• W2293676503 created "2016-06-24" @default.
• W2293676503 creator A5002567962 @default.
• W2293676503 creator A5013534831 @default.
• W2293676503 creator A5028284301 @default.
• W2293676503 creator A5034417354 @default.
• W2293676503 creator A5057257315 @default.
• W2293676503 creator A5060573192 @default.
• W2293676503 creator A5062137023 @default.
• W2293676503 creator A5070315504 @default.
• W2293676503 creator A5078348407 @default.
• W2293676503 date "2016-03-10" @default.
• W2293676503 modified "2023-10-17" @default.
• W2293676503 title "Exposure to urban PM1 in rats: development of bronchial inflammation and airway hyperresponsiveness" @default.
• W2293676503 cites W1964880971 @default.
• W2293676503 cites W1970241292 @default.
• W2293676503 cites W1979053271 @default.
• W2293676503 cites W2009018026 @default.
• W2293676503 cites W2009263098 @default.
• W2293676503 cites W2009751333 @default.
• W2293676503 cites W2012155946 @default.
• W2293676503 cites W2012476250 @default.
• W2293676503 cites W2014103421 @default.
• W2293676503 cites W2015060516 @default.
• W2293676503 cites W2024226947 @default.
• W2293676503 cites W2024853475 @default.
• W2293676503 cites W2026498095 @default.
• W2293676503 cites W2027046977 @default.
• W2293676503 cites W2033093224 @default.
• W2293676503 cites W2033551925 @default.
• W2293676503 cites W2040718810 @default.
• W2293676503 cites W2066201940 @default.
• W2293676503 cites W2071872055 @default.
• W2293676503 cites W2073974192 @default.
• W2293676503 cites W2084051196 @default.
• W2293676503 cites W2092323461 @default.
• W2293676503 cites W2094758308 @default.
• W2293676503 cites W2095591246 @default.
• W2293676503 cites W2102705244 @default.
• W2293676503 cites W2109802902 @default.
• W2293676503 cites W2110507951 @default.
• W2293676503 cites W2111839509 @default.
• W2293676503 cites W2113713722 @default.
• W2293676503 cites W2114535428 @default.
• W2293676503 cites W2115255735 @default.
• W2293676503 cites W2117793854 @default.
• W2293676503 cites W2129689267 @default.
• W2293676503 cites W2130355824 @default.
• W2293676503 cites W2140850086 @default.
• W2293676503 cites W2143645698 @default.
• W2293676503 cites W2153867951 @default.
• W2293676503 cites W2156277292 @default.
• W2293676503 cites W2167273097 @default.
• W2293676503 cites W2168783643 @default.
• W2293676503 cites W2169250251 @default.
• W2293676503 cites W2170484912 @default.
• W2293676503 cites W2171765459 @default.
• W2293676503 cites W2265913880 @default.
• W2293676503 cites W2395912414 @default.
• W2293676503 cites W2418323217 @default.
• W2293676503 cites W2990310444 @default.
• W2293676503 cites W31704534 @default.
• W2293676503 cites W5318797 @default.
• W2293676503 doi "https://doi.org/10.1186/s12931-016-0332-9" @default.
• W2293676503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4785744" @default.
• W2293676503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26966003" @default.
• W2293676503 hasPublicationYear "2016" @default.
• W2293676503 type Work @default.
• W2293676503 sameAs 2293676503 @default.
• W2293676503 citedByCount "35" @default.
• W2293676503 countsByYear W22936765032017 @default.
• W2293676503 countsByYear W22936765032018 @default.
• W2293676503 countsByYear W22936765032019 @default.
• W2293676503 countsByYear W22936765032020 @default.
• W2293676503 countsByYear W22936765032021 @default.
• W2293676503 countsByYear W22936765032022 @default.
• W2293676503 countsByYear W22936765032023 @default.
• W2293676503 crossrefType "journal-article" @default.
• W2293676503 hasAuthorship W2293676503A5002567962 @default.
• W2293676503 hasAuthorship W2293676503A5013534831 @default.
• W2293676503 hasAuthorship W2293676503A5028284301 @default.
• W2293676503 hasAuthorship W2293676503A5034417354 @default.
• W2293676503 hasAuthorship W2293676503A5057257315 @default.
• W2293676503 hasAuthorship W2293676503A5060573192 @default.
• W2293676503 hasAuthorship W2293676503A5062137023 @default.
• W2293676503 hasAuthorship W2293676503A5070315504 @default.
• W2293676503 hasAuthorship W2293676503A5078348407 @default.
• W2293676503 hasBestOaLocation W22936765031 @default.
• W2293676503 hasConcept C126322002 @default.
• W2293676503 hasConcept C142724271 @default.
• W2293676503 hasConcept C163498912 @default.
• W2293676503 hasConcept C178790620 @default.
• W2293676503 hasConcept C185592680 @default.
• W2293676503 hasConcept C203014093 @default.
• W2293676503 hasConcept C24245907 @default.
• W2293676503 hasConcept C27101514 @default.
• W2293676503 hasConcept C2776178081 @default.
• W2293676503 hasConcept C2776238763 @default.
• W2293676503 hasConcept C2776914184 @default.
• W2293676503 hasConcept C2777714996 @default.

• next