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• W2293721019 abstract "Abstract Background and Aim Patients with HIV‐hepatitis C virus (HCV) coinfection progress towards liver fibrosis and cirrhosis more rapidly compared with HCV mono‐infected individuals. This necessitates an accurate assessment of liver stiffness with transient elastography to guide treatment. Methods Searches of PubMed, EMBASE, Web of Science, and the Cochrane Library databases were performed through January 2016 to assess the diagnostic accuracy of transient elastography for liver stiffness in the HIV–HCV population. Included studies were analyzed according to the Cochrane DTA Working Group methodology. Bivariate and hierarchical models were used to compute pooled sensitivity and specificity. Positive and negative likelihood ratios were also determined. A Fagan nomogram was constructed. Meta‐regression analysis was performed with assessment of publication bias using Deeks' funnel plot asymmetry testing. Results A total of six studies ( n = 756) met the inclusion criteria. The diagnostic accuracy of elastography for the diagnosis of moderate (≥F2) fibrosis was 88% (95% confidence interval [CI], 0.85–0.90). The pooled sensitivity and specificity of moderate fibrosis was 97% (95% CI, 0.82–0.91) and 64% (95% CI, 0.45–0.79), respectively. The diagnostic accuracy of elastography for the assessment of cirrhosis was 94% (95% CI, 0.91–0.95). The pooled sensitivity and specificity for cirrhosis was 90% (95% CI, 0.74–0.97) and 87% (95% CI, 0.80–0.92), respectively. Meta‐regression analysis demonstrated that CD4 cell count did not impact diagnostic accuracy of elastography. Conclusions Transient elastography is a noninvasive imaging modality with excellent ability to assess for cirrhosis in patients with HIV–HCV coinfection." @default.
• W2293721019 created "2016-06-24" @default.
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• W2293721019 date "2016-10-01" @default.
• W2293721019 modified "2023-10-04" @default.
• W2293721019 title "Use of transient elastography in patients with HIV-HCV coinfection: A systematic review and meta-analysis" @default.
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• W2293721019 doi "https://doi.org/10.1111/jgh.13337" @default.
• W2293721019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5014713" @default.
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• W2293721019 hasPublicationYear "2016" @default.
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