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- W2293730825 abstract "Soft tissue defects are relatively common, yet currently used reconstructive treatments have varying success rates, and serious potential complications such as unpredictable volume loss and reabsorption. Human adipose-derived stem cells (ASCs), isolated from liposuction aspirate have great potential for use in soft tissue regeneration, especially when combined with a supportive scaffold. To design scaffolds that promote differentiation of these cells down an adipogenic lineage, we characterized changes in the surrounding extracellular environment during adipogenic differentiation. We found expression changes in both extracellular matrix proteins, including increases in expression of collagen-IV and vitronectin, as well as changes in the integrin expression profile, with an increase in expression of integrins such as αVβ5 and α1β1. These integrins are known to specifically interact with vitronectin and collagen-IV, respectively, through binding to an Arg-Gly-Asp (RGD) sequence. When three different short RGD-containing peptides were incorporated into three-dimensional (3D) hydrogel cultures, it was found that an RGD-containing peptide derived from vitronectin provided strong initial attachment, maintained the desired morphology, and created optimal conditions for in vitro 3D adipogenic differentiation of ASCs. These results describe a simple, nontoxic encapsulating scaffold, capable of supporting the survival and desired differentiation of ASCs for the treatment of soft tissue defects." @default.
- W2293730825 created "2016-06-24" @default.
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- W2293730825 date "2016-04-01" @default.
- W2293730825 modified "2023-10-06" @default.
- W2293730825 title "Vitronectin-Based, Biomimetic Encapsulating Hydrogel Scaffolds Support Adipogenesis of Adipose Stem Cells" @default.
- W2293730825 cites W1484931749 @default.
- W2293730825 cites W1538954095 @default.
- W2293730825 cites W1868609864 @default.
- W2293730825 cites W1973345981 @default.
- W2293730825 cites W1974452230 @default.
- W2293730825 cites W1986594503 @default.
- W2293730825 cites W1987417700 @default.
- W2293730825 cites W1987568997 @default.
- W2293730825 cites W1988645163 @default.
- W2293730825 cites W1989439356 @default.
- W2293730825 cites W1990553579 @default.
- W2293730825 cites W1991415492 @default.
- W2293730825 cites W1996966362 @default.
- W2293730825 cites W1997246078 @default.
- W2293730825 cites W2000328495 @default.
- W2293730825 cites W2002260514 @default.
- W2293730825 cites W2002535786 @default.
- W2293730825 cites W2004389193 @default.
- W2293730825 cites W2006394017 @default.
- W2293730825 cites W2006549340 @default.
- W2293730825 cites W2010320204 @default.
- W2293730825 cites W2012634392 @default.
- W2293730825 cites W2015050458 @default.
- W2293730825 cites W2016701686 @default.
- W2293730825 cites W2016832000 @default.
- W2293730825 cites W2018691366 @default.
- W2293730825 cites W2023175623 @default.
- W2293730825 cites W2023985765 @default.
- W2293730825 cites W2026632078 @default.
- W2293730825 cites W2036348189 @default.
- W2293730825 cites W2041734019 @default.
- W2293730825 cites W2043669923 @default.
- W2293730825 cites W2044801740 @default.
- W2293730825 cites W2048919244 @default.
- W2293730825 cites W2052217144 @default.
- W2293730825 cites W2053442544 @default.
- W2293730825 cites W2055491258 @default.
- W2293730825 cites W2056046349 @default.
- W2293730825 cites W2057131748 @default.
- W2293730825 cites W2060451182 @default.
- W2293730825 cites W2061010923 @default.
- W2293730825 cites W2062957606 @default.
- W2293730825 cites W2065739269 @default.
- W2293730825 cites W2067365576 @default.
- W2293730825 cites W2068969716 @default.
- W2293730825 cites W2069856608 @default.
- W2293730825 cites W2073171519 @default.
- W2293730825 cites W2078598212 @default.
- W2293730825 cites W2079711850 @default.
- W2293730825 cites W2081172134 @default.
- W2293730825 cites W2083156208 @default.
- W2293730825 cites W2085259589 @default.
- W2293730825 cites W2088056286 @default.
- W2293730825 cites W2092260050 @default.
- W2293730825 cites W2100221605 @default.
- W2293730825 cites W2100448400 @default.
- W2293730825 cites W2105300288 @default.
- W2293730825 cites W2106717149 @default.
- W2293730825 cites W2107503723 @default.
- W2293730825 cites W2107910498 @default.
- W2293730825 cites W2108083465 @default.
- W2293730825 cites W2111112139 @default.
- W2293730825 cites W2114286636 @default.
- W2293730825 cites W2115062578 @default.
- W2293730825 cites W2118544754 @default.
- W2293730825 cites W2134208433 @default.
- W2293730825 cites W2135073071 @default.
- W2293730825 cites W2138539863 @default.
- W2293730825 cites W2144023435 @default.
- W2293730825 cites W2149685956 @default.
- W2293730825 cites W2154729178 @default.
- W2293730825 cites W2167033587 @default.
- W2293730825 cites W2170651583 @default.
- W2293730825 cites W3190496831 @default.
- W2293730825 cites W322859384 @default.
- W2293730825 cites W4213141530 @default.
- W2293730825 cites W78476409 @default.
- W2293730825 doi "https://doi.org/10.1089/ten.tea.2015.0550" @default.
- W2293730825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4841091" @default.
- W2293730825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26956095" @default.
- W2293730825 hasPublicationYear "2016" @default.
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