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- W2293743957 abstract "This report describes a new three-component strategy for the regioselective synthesis of a series of tri-substituted pyridazines via a 1,4-diazabicyclo[ 2 , 2 , 2 ]octane (DABCO)-catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one-pot route toward a diverse set of 3,6-diaryl-4-methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base-organocatalyst, and affords good to excellent yields of products. This work describes the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines directly from a DABCO-catalyzed three-component condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water." @default.
- W2293743957 created "2016-06-24" @default.
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- W2293743957 date "2016-04-01" @default.
- W2293743957 modified "2023-09-29" @default.
- W2293743957 title "An environmentally-friendly base organocatalyzed one-pot strategy for the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines" @default.
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- W2293743957 doi "https://doi.org/10.1016/s1872-2067(15)61060-9" @default.
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