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• W2293776906 abstract "Fibroblast growth factor receptor 1 and 3 ( FGFR 1, FGFR 3) impact on tissue homoeostasis, embryonic development and carcinogenesis. Murine double minute protein 4 ( MDM 4) and mouse double minute 2 homologue ( MDM 2) are regulators of p53‐protein and may be the origin of an apoptosis overpowering cascade. A collective of 266 carcinomas of salivary glands were investigated for MDM 2, MDM 4, FGFR 1 and FGFR 3 aberrations by fluorescence in situ hybridization ( FISH ). The results were matched with clinicopathological parameters and with expression of PTEN and p53. MDM 2 gene amplification ( n = 9) and chromosomal aberrations (trisomy, n = 47; high polysomy, n = 7) are linked to high‐grade malignancy ( P < 0.001), lymph node metastasis ( P = 0.001), advanced tumour size ( P = 0.013) and stage ( P < 0.001), gender ( P = 0.002) and age ( P = 0.001). MDM 4 gene amplification ( n = 19) and chromosomal aberrations (trisomy, n = 34; high polysomy, n = 31) are correlated to high‐grade malignancy ( P < 0.001), lymph node metastasis ( P = 0.008), advanced tumour size ( P = 0.039), stage ( P = 0.004) and loss of PTEN ( P < 0.001). Only, high‐grade malignancy ( P < 0.001), lymph node metastasis ( P = 0.036) and advanced tumour stage ( P = 0.025) are associated with FGFR 3 amplification ( n = 1) or chromosomal aberrations (low polysomy, n = 61; high polysomy, n = 55) but not with MDM 4 alterations. FGFR 1 amplifications ( n = 5) and chromosomal aberrations (trisomy, n = 38; high polysomy, n = 30) are associated with high‐grade malignancy ( P < 0.001), advanced tumour size ( P = 0.026) and stage ( P = 0.004), gender ( P = 0.016) and age ( P = 0.023). Aberrations of MDM 2, MDM 4, FGFR 1 and FGFR 3 correlate with aggressive tumour growth and nodal metastasis. MDM 2 ( P < 0.001), MDM 4 ( P = 0.005) and FGFR 3 ( P = 0.006) alterations are associated with worse overall survival of patients with salivary gland cancer." @default.
• W2293776906 created "2016-06-24" @default.
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• W2293776906 date "2015-12-14" @default.
• W2293776906 modified "2023-10-03" @default.
• W2293776906 title "Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer" @default.
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• W2293776906 doi "https://doi.org/10.1111/jop.12394" @default.
• W2293776906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26661925" @default.
• W2293776906 hasPublicationYear "2015" @default.
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