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- W229384513 abstract "No AccessJournal of Urology1 Jul 1980Bacillus Calmette-guerin Immunotherapy of Superficial Bladder Cancer Donald L. Lamm, Daniel E. Thor, Steven C. Harris, Juan A. Reyna, Valerie D. Stogdill, and Howard M. Radwin Donald L. LammDonald L. Lamm More articles by this author , Daniel E. ThorDaniel E. Thor More articles by this author , Steven C. HarrisSteven C. Harris More articles by this author , Juan A. ReynaJuan A. Reyna More articles by this author , Valerie D. StogdillValerie D. Stogdill More articles by this author , and Howard M. RadwinHoward M. Radwin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)55282-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Thirty-seven patients were enrolled in a randomized prospective study to compare standard surgical therapy for superficial bladder cancer to standard therapy plus bacillus Calmette-Guerin (BCG). Side effects of BCG have been tolerated well and include dysuria in 95 per cent of the patients, urinary frequency in 83 per cent, hematuria in 39 per cent, fever in 22 per cent and nausea in 22 per cent. Of 19 control patients 8 (42 per cent) had recurrent tumors in the followup period, compared to 3 of 18 patients (17 per cent) treated with BCG. One patient treated with BCG had 2 recurrences, yielding a recurrence rate of 22 per cent in the group receiving BCG compared to 42 per cent in controls. When the incidence of recurrent tumors in matched intervals before and after entry into the protocol is compared, no change in the rate of tumor recurrence (p equals 0.726 chi-square) occurred in controls, whereas tumor recurrences were reduced significantly in the group treated with BCG (p equals 0.010 chi-square). The reduction in tumor recurrence in patients treated with BCG compared to controls is statistically significant (p equals 0.029 chi-square). Of 4 patients with previous stage B disease treated with BCG 3 have remained free of tumor. Three patients who presented with new bladder tumors remain free of tumor after BCG therapy, while 2 of 5 comparable control patients developed recurrent tumors. Intravesical and percutaneous BCG immunotherapy appears to decrease the rate of tumor recurrence in patients followed for 1 year. © 1980 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byMcElree I, Steinberg R, Martin A, Richards J, Mott S, Gellhaus P, Nepple K, O'Donnell M and Packiam V (2022) Sequential Intravesical Gemcitabine and Docetaxel for bacillus Calmette-Guérin-Naïve High-Risk Nonmuscle-Invasive Bladder CancerJournal of Urology, VOL. 208, NO. 3, (589-599), Online publication date: 1-Sep-2022.Donin N, Lenis A, Holden S, Drakaki A, Pantuck A, Belldegrun A and Chamie K (2018) Immunotherapy for the Treatment of Urothelial CarcinomaJournal of Urology, VOL. 197, NO. 1, (14-22), Online publication date: 1-Jan-2017.Sfakianos J, Kim P, Hakimi A and Herr H (2018) The Effect of Restaging Transurethral Resection on Recurrence and Progression Rates in Patients with Nonmuscle Invasive Bladder Cancer Treated with Intravesical Bacillus Calmette-GuérinJournal of Urology, VOL. 191, NO. 2, (341-345), Online publication date: 1-Feb-2014.Herr H and Morales A (2018) History of Bacillus Calmette-Guerin and Bladder Cancer: An Immunotherapy Success StoryJournal of Urology, VOL. 179, NO. 1, (53-56), Online publication date: 1-Jan-2008.Colombel M, Saint F, Chopin D, Malavaud B, Nicolas L and Rischmann P (2018) The Effect of Ofloxacin on Bacillus Calmette-Guerin Induced Toxicity in Patients With Superficial Bladder Cancer: Results of a Randomized, Prospective, Double-Blind, Placebo Controlled, Multicenter StudyJournal of Urology, VOL. 176, NO. 3, (935-939), Online publication date: 1-Sep-2006.PALOU J, LAGUNA P, MILLÁN-RODRÍGUEZ F, HALL R, SALVADOR-BAYARRI J and VICENTE-RODRÍGUEZ J (2018) CONTROL GROUP AND MAINTENANCE TREATMENT WITH BACILLUS CALMETTE-GUERIN FOR CARCINOMA IN SITU AND/OR HIGH GRADE BLADDER TUMORSJournal of Urology, VOL. 165, NO. 5, (1488-1491), Online publication date: 1-May-2001.LAMM D, BLUMENSTEIN B, CRISSMAN J, MONTIE J, GOTTESMAN J, LOWE B, SAROSDY M, BOHL R, GROSSMAN H, BECK T, LEIMERT J and CRAWFORD E (2018) MAINTENANCE BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY FOR RECURRENT TA, T1 AND CARCINOMA IN SITU TRANSITIONAL CELL CARCINOMA OF THE BLADDER: A RANDOMIZED SOUTHWEST ONCOLOGY GROUP STUDYJournal of Urology, VOL. 163, NO. 4, (1124-1129), Online publication date: 1-Apr-2000.ALI-EL-DEIN B, NABEEH A, ISMAIL E and GHONEIM M (2018) SEQUENTIAL BACILLUS CALMETTE-GUERIN AND EPIRUBICIN VERSUS BACILLUS CALMETTE-GUERIN ALONE FOR SUPERFICIAL BLADDER TUMORS: A RANDOMIZED PROSPECTIVE STUDYJournal of Urology, VOL. 162, NO. 2, (339-342), Online publication date: 1-Aug-1999.Wishahi M, Ismail I, Ruebben H and Otto T (2018) Original Articles: Bladder Cancer: Keyhole-Limpet Hemocyanin Immunotherapy in the Bilharzial Bladder: A New Treatment Modality? Phase II Trial: Superficial Bladder CancerJournal of Urology, VOL. 153, NO. 3S, (926-928), Online publication date: 1-Mar-1995.Lamm D, Riggs D, Shriver J, vanGilder P, Rach J and DeHaven J (2018) Megadose Vitamins in Bladder Cancer: A Double-Blind Clinical TrialJournal of Urology, VOL. 151, NO. 1, (21-26), Online publication date: 1-Jan-1994.Hakim S, Heaney J, Heinz T and Zwolak R (2018) Psoas Abscess Following Intravesical Bacillus Calmette-Guerin for Bladder Cancer: A Case ReportJournal of Urology, VOL. 150, NO. 1, (188-189), Online publication date: 1-Jul-1993.Cookson M and Sarosdy M (2018) Management of Stage T1 Superficial Bladder Cancer with Intravesical Bacillus Calmette-Guerin TherapyJournal of Urology, VOL. 148, NO. 3 Part 1, (797-801), Online publication date: 1-Sep-1992.Molina J, Rabian C, D’agay M and Modai J (2018) Hypersen sitivity Systemic Reaction Following Intravesical Bacillus Calmette-Guerin: Successful Treatment With SteroidsJournal of Urology, VOL. 147, NO. 3 Part 1, (695-697), Online publication date: 1-Mar-1992.Levi D’Ancona C, Rodrigues Netto N, Almeida Claro J and Ikari O (2018) Oral or Intravesical Bacillus Calmette-Guerin Immunoprophylaxis in Bladder CarcinomaJournal of Urology, VOL. 145, NO. 3, (498-501), Online publication date: 1-Mar-1991.Martínez Piñeiro J, León J, Martínez Piñeiro L, Fiter L, Mosteiro J, Navarro J, García Matres M and Cárcamo P (2018) Bacillus Calmette-Guerin Versus Doxorubicin Versus Thiotepa: A Randomized Prospective Study in 202 Patients with Superficial Bladder CancerJournal of Urology, VOL. 143, NO. 3, (502-506), Online publication date: 1-Mar-1990.Sarosdy M and Lamm D (2018) Long-Term Results of Intravesical Bacillus Calmette-Guerin Therapy for Superficial Bladder CancerJournal of Urology, VOL. 142, NO. 3, (719-722), Online publication date: 1-Sep-1989.Herr H (2018) Editorial CommentJournal of Urology, VOL. 142, NO. 3, (722-722), Online publication date: 1-Sep-1989.Linn R, Klimberg I and Wajsman Z (2018) Persistent Acid-Fast Bacilli Following Intravesical Bacillus Calmette-GuerinJournal of Urology, VOL. 141, NO. 5, (1197-1198), Online publication date: 1-May-1989.Ibrahiem E, Ghoneim M, Nigam V, Brailovsky C and Elhilali M (2018) Prophylactic Maltose Tetrapalmitate and Bacillus Calmette-Guerin Immunotherapy of Recurrent Superficial Bladder Tumors: Preliminary ReportJournal of Urology, VOL. 140, NO. 3, (498-500), Online publication date: 1-Sep-1988.Torrence R, Kavoussi L, Catalona W and Ratliff T (2018) Prognostic Factors in Patients Treated with Intravesical Bacillus Calmette-Guerin for Superficial Bladder CancerJournal of Urology, VOL. 139, NO. 5, (941-944), Online publication date: 1-May-1988.Bahnson R and Ratliff T (2018) Inhibition of Mouse Bladder Tumor Proliferation by Alpha Difluoromethylornithine and Interferon in Vitro and in VivoJournal of Urology, VOL. 139, NO. 6, (1367-1371), Online publication date: 1-Jun-1988.Hudson M, Ratliff T, Gillen D, Haaff E, Dresner S and Catalona W (2018) Single Course Versus Maintenance Bacillus Calmette-Guerin Therapy for Superficial Bladder Tumors: A Prospective, Randomized TrialJournal of Urology, VOL. 138, NO. 2, (295-298), Online publication date: 1-Aug-1987.DeKernion J (2018) Editorial CommentsJournal of Urology, VOL. 138, NO. 2, (298-298), Online publication date: 1-Aug-1987.Pansadoro V and De Paula F (2018) Intravesical Bacillus Calmette-Guerin in the Treatment of Superficial Transitional Cell Carcinoma of the BladderJournal of Urology, VOL. 138, NO. 2, (299-301), Online publication date: 1-Aug-1987.Jakse G, Loidl W, Seeber G and Hofstädter F (2018) Stage T1, Grade 3 Transitional Cell Carcinoma of the Bladder: An Unfavorable Tumor?Journal of Urology, VOL. 137, NO. 1, (39-43), Online publication date: 1-Jan-1987.Merguerian P, Donahue L and Cockett A (2018) Intraluminal Interleukin 2 and Bacillus Calmette-Guerin for Treatment of Bladder Cancer: A Preliminary ReportJournal of Urology, VOL. 137, NO. 2, (216-219), Online publication date: 1-Feb-1987.Marsh C, Torrey R, Woolley J, Barker G and Lau B (2018) Superiority of Intravesical Immunotherapy with Corynebacterium Parvum and Allium Sativum in Control of Murine Bladder CancerJournal of Urology, VOL. 137, NO. 2, (359-362), Online publication date: 1-Feb-1987.Huland H, Arndt R, Huland E, Loening T and Steffens M (2018) Monoclonal Antibody 486 P 3/12: A Valuable Bladder Carcinoma Marker for ImmunocytologyJournal of Urology, VOL. 137, NO. 4, (654-659), Online publication date: 1-Apr-1987.Soloway M and Perry A (2018) Bacillus Calmette-Guerin for Treatment of Superficial Transitional Cell Carcinoma of the Bladder in Patients who have failed Thiotepa and/or Mitomycin CJournal of Urology, VOL. 137, NO. 5, (871-873), Online publication date: 1-May-1987.Catalona W (2018) Editorial CommentJournal of Urology, VOL. 137, NO. 5, (873-873), Online publication date: 1-May-1987.Lamm D (2018) Editorial CommentsJournal of Urology, VOL. 138, NO. 2, (298-298), Online publication date: 1-Aug-1987. (2018) Reply by AuthorsJournal of Urology, VOL. 138, NO. 2, (298-298), Online publication date: 1-Aug-1987.Haaff E, Dresner S, Ratliff T and Catalona W (2018) Two Courses of Intravesical Bacillus Calmette-Guerin for Transitional Cell Carcinoma of the BladderJournal of Urology, VOL. 136, NO. 4, (820-823), Online publication date: 1-Oct-1986.Lamm D (2018) Editorial CommentJournal of Urology, VOL. 136, NO. 4, (823-824), Online publication date: 1-Oct-1986.Klimberg I and Wajsman Z (2018) Treatment for Muscle Invasive Carcinoma of the BladderJournal of Urology, VOL. 136, NO. 6, (1169-1175), Online publication date: 1-Dec-1986.Kelley D, Haaff E, Becich M, Lage J, Bauer W, Dresner S, Catalona W and Ratliff T (2018) Prognostic Value of Purified Protein Derivative Skin Test and Granuloma Formation in Patients Treated with Intravesical Bacillus Calmette-GuerinJournal of Urology, VOL. 135, NO. 2, (268-271), Online publication date: 1-Feb-1986.Droller M (2018) Bacillus Calmette-Guerin in the Management of Bladder CancerJournal of Urology, VOL. 135, NO. 2, (331-333), Online publication date: 1-Feb-1986.Brosman S (2018) The Use of Bacillus Calmette-Guerin in the Therapy of Bladder Carcinoma in SituJournal of Urology, VOL. 134, NO. 1, (36-39), Online publication date: 1-Jul-1985.Lamm D (2018) Bacillus Calmette-Guerin Immunotherapy for Bladder CancerJournal of Urology, VOL. 134, NO. 1, (40-46), Online publication date: 1-Jul-1985.Catalona W (2018) Editorial CommentsJournal of Urology, VOL. 134, NO. 1, (46-47), Online publication date: 1-Jul-1985.Droller M (2018) Immunotherapy in Genitourinary NeoplasiaJournal of Urology, VOL. 133, NO. 1, (1-5), Online publication date: 1-Jan-1985.Morales A (2018) Long-Term Results and Complications of Intracavitary Bacillus Calmette-Guerin Therapy for Bladder CancerJournal of Urology, VOL. 132, NO. 3, (457-459), Online publication date: 1-Sep-1984.Netto N and Lemos G (2018) Bacillus Calmette-Guerin Immunotherapy of Infiltrating Bladder CancerJournal of Urology, VOL. 132, NO. 4, (675-676), Online publication date: 1-Oct-1984.Lamm D (2018) Editorial CommentsJournal of Urology, VOL. 132, NO. 4, (676-676), Online publication date: 1-Oct-1984.Droller M (2018) Editorial CommentsJournal of Urology, VOL. 132, NO. 4, (676-677), Online publication date: 1-Oct-1984.Adolphs H and Bastian H (2018) Chemoimmune Prophylaxis of Superficial Bladder CancerJournal of Urology, VOL. 129, NO. 1, (29-31), Online publication date: 1-Jan-1983.Mcroberts J (2018) Editorial CommentJournal of Urology, VOL. 129, NO. 1, (31-32), Online publication date: 1-Jan-1983.Brosman S (2018) Experience with Bacillus Calmette-Guerin in Patients with Superficial Bladder CarcinomaJournal of Urology, VOL. 128, NO. 1, (27-30), Online publication date: 1-Jul-1982.Lamm D, Thor D, Stogdill V and Radwin H (2018) Bladder Cancer ImmunotherapyJournal of Urology, VOL. 128, NO. 5, (931-935), Online publication date: 1-Nov-1982. (2018) Reply by AuthorsJournal of Urology, VOL. 127, NO. 2, (235-235), Online publication date: 1-Feb-1982.Morales A, Ottenhof P and Emerson L (2018) Treatment of Residual, Non-infiltrating Bladder Cancer with Bacillus Calmette-guerinJournal of Urology, VOL. 125, NO. 5, (649-651), Online publication date: 1-May-1981. Volume 124Issue 1July 1980Page: 38-42 Advertisement Copyright & Permissions© 1980 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Donald L. Lamm More articles by this author Daniel E. Thor More articles by this author Steven C. Harris More articles by this author Juan A. Reyna More articles by this author Valerie D. Stogdill More articles by this author Howard M. Radwin More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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