FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2293883325> ?p ?o ?g. }

• W2293883325 endingPage "240" @default.
• W2293883325 startingPage "239" @default.
• W2293883325 abstract "Background/Aims: Nonalcoholic fatty liver disease is related with obesity and hyperlipidemia. PPAR α is highly expressed and promotes fatty acid oxidation by PPAR α agonists or inhibits fat denaturalization in liver. The aim of this study is to elucidate the effect of PPAR α agonist on rat liver and fatty acid oxidative metabolism of hepatocytes in hyperlipidemic condition. Methods: Male Splague Dawley rats were divided into 3 groups; fed normal diet, high fat diet (containing 40% fat), and high fat diet with fenofibrate (100 mg/day) for 10 weeks. After sacrificing, the concentrations of adiponectin, leptin, and HDL in serum was measured by ELISA or RIA. The fat contents in liver were determined by H & E staining method. The effects of PPAR α agonist in HepG2 cells exposed to high fatty acid (0.1 mM palmitate) were also determined by RT-PCR for fatty acid binding protein (FABP), carnitine palmitoyltransferase I (CPT I), medium chain acyl-CoA dehydrogenase (MCAD) and Western blot analyses for MCAD and PPAR α. Results: Diet intake, body weight, and fat weight in the group fed PPAR α agonist were decreased by 22.4%, 39.4% and 30.7% respectively compared to the group fed only high fat diet. Adiponectin, leptin, and HDL were increased by 370%, 141%, and 196% in group fed PPAR α agonist. Lipid droplets were clearly observed in liver of the rats fed high fat diet, however, they were never viewed in liver treated by PPAR α agonist In HepG2 cells, the mRNA levels of MCAD, FABP and CPT I decreased by hyperlipidemic condition were increased significantly by treatments of PPAR α agonist, and the protein expression levels of MCAD and PPAR α were elevated by PPAR α agonist in hyperlipidemic condition. Conclusions: In hyperlipidemic condition, PPAR α agonist seems to reduce appetite through increasing of leptin level and inhibit fat accumulation via elevating of adiponectin in rat and may ameliorate fatty acid oxidative metabolism in HepG2 cells. Consequently, it was supposed that PPAR α agonist can inhibit early fatty liver disease." @default.
• W2293883325 created "2016-06-24" @default.
• W2293883325 creator A5000708221 @default.
• W2293883325 creator A5008755364 @default.
• W2293883325 creator A5014754422 @default.
• W2293883325 creator A5031992462 @default.
• W2293883325 creator A5043831059 @default.
• W2293883325 creator A5062763707 @default.
• W2293883325 creator A5064363666 @default.
• W2293883325 date "2007-01-01" @default.
• W2293883325 modified "2023-09-28" @default.
• W2293883325 title "Disorders of Liver : Effect of Peroxisome Proliferator-Activated Receptor A (PPARA) Agonist On Liver In Hyperlipidemic Condition" @default.
• W2293883325 hasPublicationYear "2007" @default.
• W2293883325 type Work @default.
• W2293883325 sameAs 2293883325 @default.
• W2293883325 citedByCount "0" @default.
• W2293883325 crossrefType "journal-article" @default.
• W2293883325 hasAuthorship W2293883325A5000708221 @default.
• W2293883325 hasAuthorship W2293883325A5008755364 @default.
• W2293883325 hasAuthorship W2293883325A5014754422 @default.
• W2293883325 hasAuthorship W2293883325A5031992462 @default.
• W2293883325 hasAuthorship W2293883325A5043831059 @default.
• W2293883325 hasAuthorship W2293883325A5062763707 @default.
• W2293883325 hasAuthorship W2293883325A5064363666 @default.
• W2293883325 hasConcept C126322002 @default.
• W2293883325 hasConcept C127078168 @default.
• W2293883325 hasConcept C134018914 @default.
• W2293883325 hasConcept C170493617 @default.
• W2293883325 hasConcept C185592680 @default.
• W2293883325 hasConcept C187345961 @default.
• W2293883325 hasConcept C2776423169 @default.
• W2293883325 hasConcept C2776614356 @default.
• W2293883325 hasConcept C2776782570 @default.
• W2293883325 hasConcept C2776954865 @default.
• W2293883325 hasConcept C2777391703 @default.
• W2293883325 hasConcept C2778110834 @default.
• W2293883325 hasConcept C2778435403 @default.
• W2293883325 hasConcept C2778772119 @default.
• W2293883325 hasConcept C2778938600 @default.
• W2293883325 hasConcept C2779091943 @default.
• W2293883325 hasConcept C2779134260 @default.
• W2293883325 hasConcept C44353895 @default.
• W2293883325 hasConcept C511355011 @default.
• W2293883325 hasConcept C543025807 @default.
• W2293883325 hasConcept C55493867 @default.
• W2293883325 hasConcept C555293320 @default.
• W2293883325 hasConcept C62231903 @default.
• W2293883325 hasConcept C71924100 @default.
• W2293883325 hasConcept C82714985 @default.
• W2293883325 hasConcept C86803240 @default.
• W2293883325 hasConceptScore W2293883325C126322002 @default.
• W2293883325 hasConceptScore W2293883325C127078168 @default.
• W2293883325 hasConceptScore W2293883325C134018914 @default.
• W2293883325 hasConceptScore W2293883325C170493617 @default.
• W2293883325 hasConceptScore W2293883325C185592680 @default.
• W2293883325 hasConceptScore W2293883325C187345961 @default.
• W2293883325 hasConceptScore W2293883325C2776423169 @default.
• W2293883325 hasConceptScore W2293883325C2776614356 @default.
• W2293883325 hasConceptScore W2293883325C2776782570 @default.
• W2293883325 hasConceptScore W2293883325C2776954865 @default.
• W2293883325 hasConceptScore W2293883325C2777391703 @default.
• W2293883325 hasConceptScore W2293883325C2778110834 @default.
• W2293883325 hasConceptScore W2293883325C2778435403 @default.
• W2293883325 hasConceptScore W2293883325C2778772119 @default.
• W2293883325 hasConceptScore W2293883325C2778938600 @default.
• W2293883325 hasConceptScore W2293883325C2779091943 @default.
• W2293883325 hasConceptScore W2293883325C2779134260 @default.
• W2293883325 hasConceptScore W2293883325C44353895 @default.
• W2293883325 hasConceptScore W2293883325C511355011 @default.
• W2293883325 hasConceptScore W2293883325C543025807 @default.
• W2293883325 hasConceptScore W2293883325C55493867 @default.
• W2293883325 hasConceptScore W2293883325C555293320 @default.
• W2293883325 hasConceptScore W2293883325C62231903 @default.
• W2293883325 hasConceptScore W2293883325C71924100 @default.
• W2293883325 hasConceptScore W2293883325C82714985 @default.
• W2293883325 hasConceptScore W2293883325C86803240 @default.
• W2293883325 hasLocation W22938833251 @default.
• W2293883325 hasOpenAccess W2293883325 @default.
• W2293883325 hasPrimaryLocation W22938833251 @default.
• W2293883325 hasRelatedWork W1693042156 @default.
• W2293883325 hasRelatedWork W1998964189 @default.
• W2293883325 hasRelatedWork W2021474423 @default.
• W2293883325 hasRelatedWork W2061014186 @default.
• W2293883325 hasRelatedWork W2062229082 @default.
• W2293883325 hasRelatedWork W2069205903 @default.
• W2293883325 hasRelatedWork W2127614696 @default.
• W2293883325 hasRelatedWork W2361052857 @default.
• W2293883325 hasRelatedWork W2361953760 @default.
• W2293883325 hasRelatedWork W2376942254 @default.
• W2293883325 hasRelatedWork W2381759236 @default.
• W2293883325 hasRelatedWork W2383278591 @default.
• W2293883325 hasRelatedWork W2402828275 @default.
• W2293883325 hasRelatedWork W2560077762 @default.
• W2293883325 hasRelatedWork W2591071429 @default.
• W2293883325 hasRelatedWork W2895085109 @default.
• W2293883325 hasRelatedWork W2900154505 @default.
• W2293883325 hasRelatedWork W3033652696 @default.
• W2293883325 hasRelatedWork W3112466780 @default.

• next