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• W2293977208 abstract "Matrix metalloproteinases (MMPs) are classified in the family of zinc-dependent endopeptidases, which can degrade various components of an extracellular matrix and a basement membrane. Studies have demonstrated that MMPs relate to the development of malignant tumors and induce angiogenesis, resulting in the invasion and metastasis of tumor cells. MMPs are highly expressed in malignant tumors and are related to cancer patients' malignant phenotype and poor prognosis. Therefore, blocking the expression or activity of MMPs may be a promising strategy for cancer treatment.This study aimed to explain the MMP structure, regulatory mechanism, and carcinogenic effect; investigate the matrix metalloproteinase-inhibitors (MMPIs) that are currently used in clinical trials for cancer treatment; and summarize the trial results.Currently, the results of clinical trials that have used MMPIs as anticancer agents are unsatisfactory. However, MMPs remain an attractive target for cancer treatment. For example, development of the specific peptide or antibodies in targeting the hemopexin domain of MMP-2 may be a new therapeutic direction. The design and development of MMPIs that have selectivity will be the primary focus in future studies." @default.
• W2293977208 created "2016-06-24" @default.
• W2293977208 creator A5016067283 @default.
• W2293977208 creator A5039567335 @default.
• W2293977208 creator A5069283565 @default.
• W2293977208 date "2016-01-11" @default.
• W2293977208 modified "2023-10-03" @default.
• W2293977208 title "Pharmacodynamic considerations in the use of matrix metalloproteinase inhibitors in cancer treatment" @default.
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• W2293977208 doi "https://doi.org/10.1517/17425255.2016.1131820" @default.
• W2293977208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26852787" @default.
• W2293977208 hasPublicationYear "2016" @default.
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