FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2294095024> ?p ?o ?g. }

• W2294095024 endingPage "161" @default.
• W2294095024 startingPage "140" @default.
• W2294095024 abstract "Various metals have demonstrated genotoxic and carcinogenic potential via different mechanisms. Until now, biomonitoring and epidemiological studies have been carried out to assess the genotoxic risk to exposed human populations. In this sense, the use of the micronucleus assay in peripheral blood lymphocytes has proven to be a useful tool to determine increased levels of DNA damage, as a surrogate biomarker of cancer risk. Here we review those biomonitoring studies focused on people exposed to arsenic, chromium, nickel, vanadium and complex mixtures of metals. Only those studies that used the frequency of micronuclei in binucleated (BNMN) cells have been taken into consideration, although the inclusion of other biomarkers of exposure and genotoxicity are also reflected and discussed. Regarding arsenic, most of the occupational and environmental biomonitoring studies find an increase in BNMN among the exposed individuals. Thus, it seems conclusive that arsenic exposure increases the risk of exposed human populations. However, a lack of correlation between the level of exposure and the increase in BNMN is also common, and a limited number of studies evaluated the genotype as a risk modulator. As for chromium, a BNMN increase in occupationally exposed subjects and a correlation between level of exposure and effect is found consistently in the available literature. However, the quality score of the studies is only medium-low. On the other hand, the studies evaluating nickel and vanadium are scarce and lacks a correct characterization of the individual exposure, which difficult the building of clear conclusions. Finally, several studies with medium-high quality scores evaluated a more realistic scenario of exposure which takes into account a mixture of metals. Among them, those which correctly characterized and measured the exposure were able to find association with the level of BNMN. Also, several genes associated with DNA damage repair such as OGG1 and XRCC1 were found to influence the exposure effect." @default.
• W2294095024 created "2016-06-24" @default.
• W2294095024 creator A5000064654 @default.
• W2294095024 creator A5006694484 @default.
• W2294095024 creator A5012415632 @default.
• W2294095024 creator A5028649970 @default.
• W2294095024 date "2016-10-01" @default.
• W2294095024 modified "2023-10-02" @default.
• W2294095024 title "Biomonitoring of humans exposed to arsenic, chromium, nickel, vanadium, and complex mixtures of metals by using the micronucleus test in lymphocytes" @default.
• W2294095024 cites W1570986866 @default.
• W2294095024 cites W1607724276 @default.
• W2294095024 cites W1643589044 @default.
• W2294095024 cites W178677290 @default.
• W2294095024 cites W1886824159 @default.
• W2294095024 cites W1963532049 @default.
• W2294095024 cites W1967959518 @default.
• W2294095024 cites W1968188089 @default.
• W2294095024 cites W1972134770 @default.
• W2294095024 cites W1972754197 @default.
• W2294095024 cites W1973753201 @default.
• W2294095024 cites W1974140466 @default.
• W2294095024 cites W1975230218 @default.
• W2294095024 cites W1977624169 @default.
• W2294095024 cites W1978620033 @default.
• W2294095024 cites W1979112811 @default.
• W2294095024 cites W1980544249 @default.
• W2294095024 cites W1987725436 @default.
• W2294095024 cites W1990765808 @default.
• W2294095024 cites W1992464303 @default.
• W2294095024 cites W1995338674 @default.
• W2294095024 cites W1995461126 @default.
• W2294095024 cites W1999031124 @default.
• W2294095024 cites W2001951303 @default.
• W2294095024 cites W2002389528 @default.
• W2294095024 cites W2002701234 @default.
• W2294095024 cites W2003021146 @default.
• W2294095024 cites W2007697781 @default.
• W2294095024 cites W2008353144 @default.
• W2294095024 cites W2012333061 @default.
• W2294095024 cites W2012519345 @default.
• W2294095024 cites W2017357811 @default.
• W2294095024 cites W2017682087 @default.
• W2294095024 cites W2018596367 @default.
• W2294095024 cites W2018682497 @default.
• W2294095024 cites W2018907356 @default.
• W2294095024 cites W2019127055 @default.
• W2294095024 cites W2019450870 @default.
• W2294095024 cites W2027307634 @default.
• W2294095024 cites W2028037043 @default.
• W2294095024 cites W2029367870 @default.
• W2294095024 cites W2029794286 @default.
• W2294095024 cites W2032791767 @default.
• W2294095024 cites W2038461910 @default.
• W2294095024 cites W2039490718 @default.
• W2294095024 cites W2040143609 @default.
• W2294095024 cites W2041467669 @default.
• W2294095024 cites W2041830360 @default.
• W2294095024 cites W2044782023 @default.
• W2294095024 cites W2044919336 @default.
• W2294095024 cites W2046471358 @default.
• W2294095024 cites W2048747342 @default.
• W2294095024 cites W2049928792 @default.
• W2294095024 cites W2052402304 @default.
• W2294095024 cites W2054005522 @default.
• W2294095024 cites W2058827343 @default.
• W2294095024 cites W2059841058 @default.
• W2294095024 cites W2061098044 @default.
• W2294095024 cites W2061821538 @default.
• W2294095024 cites W2062468532 @default.
• W2294095024 cites W2062896439 @default.
• W2294095024 cites W2063318140 @default.
• W2294095024 cites W2063570260 @default.
• W2294095024 cites W2066748372 @default.
• W2294095024 cites W2067606064 @default.
• W2294095024 cites W2068640175 @default.
• W2294095024 cites W2068825410 @default.
• W2294095024 cites W2071152209 @default.
• W2294095024 cites W2074542088 @default.
• W2294095024 cites W2076000174 @default.
• W2294095024 cites W2076405005 @default.
• W2294095024 cites W2076950775 @default.
• W2294095024 cites W2079628124 @default.
• W2294095024 cites W2080723329 @default.
• W2294095024 cites W2082981422 @default.
• W2294095024 cites W2084947612 @default.
• W2294095024 cites W2090068879 @default.
• W2294095024 cites W2090457294 @default.
• W2294095024 cites W2090818338 @default.
• W2294095024 cites W2102319964 @default.
• W2294095024 cites W2104248159 @default.
• W2294095024 cites W2106113361 @default.
• W2294095024 cites W2106625186 @default.
• W2294095024 cites W2112784018 @default.
• W2294095024 cites W2112865167 @default.
• W2294095024 cites W2114646867 @default.
• W2294095024 cites W2116543832 @default.
• W2294095024 cites W2119285674 @default.
• W2294095024 cites W2124337153 @default.

• next