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- W2294130770 endingPage "2144" @default.
- W2294130770 startingPage "2129" @default.
- W2294130770 abstract "Like other obligate intracellular bacteria, the Chlamydiae feature a compact regulatory genome that remains uncharted owing to poor genetic tractability. Exploiting the reduced number of transcription factors (TFs) encoded in the chlamydial (pan-)genome as a model for TF control supporting the intracellular lifestyle, we determined the conserved landscape of TF specificities by ChIP-Seq (chromatin immunoprecipitation-sequencing) in the chlamydial pathogen Waddlia chondrophila. Among 10 conserved TFs, Euo emerged as a master TF targeting >100 promoters through conserved residues in a DNA excisionase-like winged helix-turn-helix-like (wHTH) fold. Minimal target (Euo) boxes were found in conserved developmentally-regulated genes governing vertical genome transmission (cytokinesis and DNA replication) and genome plasticity (transposases). Our ChIP-Seq analysis with intracellular bacteria not only reveals that global TF regulation is maintained in the reduced regulatory genomes of Chlamydiae, but also predicts that master TFs interpret genomic information in the obligate intracellular α-proteobacteria, including the rickettsiae, from which modern day mitochondria evolved." @default.
- W2294130770 created "2016-06-24" @default.
- W2294130770 creator A5022168227 @default.
- W2294130770 creator A5038932562 @default.
- W2294130770 creator A5038940504 @default.
- W2294130770 creator A5064150176 @default.
- W2294130770 creator A5068172675 @default.
- W2294130770 creator A5084747863 @default.
- W2294130770 creator A5087817053 @default.
- W2294130770 date "2016-03-08" @default.
- W2294130770 modified "2023-09-26" @default.
- W2294130770 title "Regulatory (pan-)genome of an obligate intracellular pathogen in the PVC superphylum" @default.
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