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• W2294307612 abstract "We consider PDE/ODE systems for the simulation of intercellular signaling in multicellular environments. The intracellular processes for each cell described here by ODEs determine the long-time dynamics, but the PDE part dominates the solving effort. Thus, it is not clear if commonly used decoupling methods can outperform a coupling approach. Based on a sensitivity analysis, we present a systematic comparison between coupling and decoupling approaches for this class of problems and show numerical results. For biologically relevant configurations of the model, our quantitative study shows that a coupling approach performs much better than a decoupling one." @default.
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• W2294307612 date "2016-06-01" @default.
• W2294307612 modified "2023-09-24" @default.
• W2294307612 title "Coupling vs decoupling approaches for PDE/ODE systems modeling intercellular signaling" @default.
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• W2294307612 doi "https://doi.org/10.1016/j.jcp.2016.03.020" @default.
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