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- W2294328126 abstract "Understanding the mechanism of tumor cell extravasation, cell migration and the role of the immunosystem is crucial in creating targeted and patient-specific cancer therapies. We created an in-vitro microfluidic cell extravasation assay, incorporating a microvascular network and demonstrated its use to study cancer cells extravasation. Separately, we developed an assay for screening T-cell migration and cytotoxicity as a means to evaluate the efficiency of adoptive immunotherapies against cancer. Similar devices using a similar platform can be used to recreate a tumor liver microenvironment, taking in consideration the hypoxic and inflammatory conditions in the liver. These platforms show considerable potential as efficient pre-clinical models for testing the efficiency of cancer drugs and engineered T-cell functionality for personalized medicine." @default.
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- W2294328126 date "2015-08-01" @default.
- W2294328126 modified "2023-10-01" @default.
- W2294328126 title "Using microfluidics to investigate tumor cell extravasation and T-cell immunotherapies" @default.
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- W2294328126 doi "https://doi.org/10.1109/embc.2015.7318742" @default.
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