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- W2294334225 abstract "Abstract Bone homeostasis is maintained by balancing bone formation and bone resorption, but an imbalance between them is associated with various bone-related diseases such as osteoporosis and rheumatoid arthritis. We found that 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK), which were isolated as promising compounds from Alpinia zerumbet rhizomes, promote differentiation of osteoblastic MC3T3-E1 cells. DK and DDK increased the alkaline phosphatase activity and matrix mineralization of MC3T3-E1 cells. DK exerts larger effects than DDK. The gene expression of runt-related transcription factor 2 and osterix, which are essential transcription factors in the early period of osteoblast differentiation, was significantly increased by DK treatment. The mRNA level of distal-less homeobox 5 was also enhanced by DK treatment, and DK activated the p38 mitogen-activated protein kinase pathway. Therefore, DK may have clinical potential for preventing osteoporosis, and could be considered as a potential anabolic therapeutic agent." @default.
- W2294334225 created "2016-06-24" @default.
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- W2294334225 date "2016-07-02" @default.
- W2294334225 modified "2023-10-02" @default.
- W2294334225 title "5,6-Dehydrokawain from <i>Alpinia zerumbet</i> promotes osteoblastic MC3T3-E1 cell differentiation" @default.
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- W2294334225 doi "https://doi.org/10.1080/09168451.2016.1153959" @default.
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