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• W2294513232 endingPage "66" @default.
• W2294513232 startingPage "58" @default.
• W2294513232 abstract "In contrast to mammals, where a single proglucagon (PG) gene encodes three peptides: glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 (GLP-1; GLP-2), many non-mammalian vertebrates carry multiple PG genes. Here, we investigate proglucagon mRNA sequences, their tissue expression and processing in a diploid bony fish. Copper rockfish (Sebastes caurinus) express two independent genes coding for distinct proglucagon sequences (PG I, PG II), with PG II lacking the GLP-2 sequence. These genes are differentially transcribed in the endocrine pancreas, the brain, and the gastrointestinal tract. Alternative splicing identified in rockfish is only one part of this complex regulation of the PG transcripts: the system has the potential to produce two glucagons, four GLP-1s and a single GLP-2, or any combination of these peptides. Mass spectrometric analysis of partially purified PG-derived peptides in endocrine pancreas confirms translation of both PG transcripts and differential processing of the resulting peptides. The complex differential regulation of the two PG genes and their continued presence in this extant teleostean fish strongly suggests unique and, as yet largely unidentified, roles for the peptide products encoded in each gene." @default.
• W2294513232 created "2016-06-24" @default.
• W2294513232 creator A5048932799 @default.
• W2294513232 creator A5055997884 @default.
• W2294513232 date "2016-09-01" @default.
• W2294513232 modified "2023-09-24" @default.
• W2294513232 title "Proglucagons in vertebrates: Expression and processing of multiple genes in a bony fish" @default.
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• W2294513232 doi "https://doi.org/10.1016/j.cbpb.2016.02.004" @default.
• W2294513232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26927880" @default.
• W2294513232 hasPublicationYear "2016" @default.
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