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• W2294575478 abstract "The composition of human skin acts as a natural habitat for various bacterial species that function in a commensal and symbiotic fashion. In a healthy individual, bacterial flora serves to protect the host. Under certain conditions such as minor trauma, impaired host immunity, or environmental factors, the risk of developing skin infections is increased. Although a large majority of bacterial associated skin infections are common, a portion can potentially manifest into clinically significant morbidity. For example, Gram positive species that typically reside on the skin such as Staphylococcus and Streptococcus can cause numerous epidermal (impetigo, ecthyma) and dermal (cellulitis, necrotizing fasciitis, erysipelas) skin infections. Moreover, the increasing incidence of bacterial antibiotic resistance represents a serious challenge to modern medicine and threatens the health care system. Therefore, it is critical to develop tools and strategies that can allow us to better elucidate the nature and mechanism of bacterial virulence. To this end, mass spectrometry (MS)-based proteomics has been revolutionizing biomedical research, and has positively impacted the microbiology field. Advances in MS technologies have paved the way for numerous bacterial proteomes and their respective post translational modifications (PTMs) to be accurately identified and quantified in a high throughput and robust fashion. This technological platform offers critical information with regards to signal transduction, adherence, and microbial-host interactions associated with bacterial pathogenesis. This mini-review serves to highlight the current progress proteomics has contributed towards the understanding of bacteria that are associated with skin related diseases, infections, and antibiotic resistance." @default.
• W2294575478 created "2016-06-24" @default.
• W2294575478 creator A5032961429 @default.
• W2294575478 creator A5075017178 @default.
• W2294575478 date "2016-02-19" @default.
• W2294575478 modified "2023-10-17" @default.
• W2294575478 title "Mass Spectrometry-Based Bacterial Proteomics: Focus on Dermatologic Microbial Pathogens" @default.
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• W2294575478 doi "https://doi.org/10.3389/fmicb.2016.00181" @default.
• W2294575478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4759281" @default.
• W2294575478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26925048" @default.
• W2294575478 hasPublicationYear "2016" @default.
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