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- W2294611182 abstract "Microelectrode array (MEA) technology enables advanced drug screening and “disease-in-a-dish” modeling by measuringthe electrical activity of cultured networks of neural or cardiac cells. Recent developments in human stem cell technologies,advancements in genetic models, and regulatory initiatives for drug screening have increased the demand for MEA-basedassays. In response, Axion Biosystems previously developed a multiwell MEA platform, providing up to 96 MEA culturewells arrayed into a standard microplate format.Multiwell MEA-based assays would be further enhanced by optogenetic stimulation, which enables selective excitationand inhibition of targeted cell types. This capability for selective control over cell culture states would allow finer pacingand probing of cell networks for more reliable and complete characterization of complex network dynamics.Here we describe a system for independent optogenetic stimulation of each well of a 48-well MEA plate. The systemenables finely graded control of light delivery during simultaneous recording of network activity in each well. Usinghuman induced pluripotent stem cell (hiPSC) derived cardiomyocytes and rodent primary neuronal cultures, wedemonstrate high channel-count light-based excitation and suppression in several proof-of-concept experimental models.Our findings demonstrate advantages of combining multiwell optical stimulation and MEA recording for applicationsincluding cardiac safety screening, neural toxicity assessment, and advanced characterization of complex neuronaldiseases." @default.
- W2294611182 created "2016-06-24" @default.
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- W2294611182 date "2016-03-09" @default.
- W2294611182 modified "2023-09-23" @default.
- W2294611182 title "Optogenetic stimulation of multiwell MEA plates for neural and cardiac applications" @default.
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- W2294611182 doi "https://doi.org/10.1117/12.2213708" @default.
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