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- W2294802009 abstract "The human epiderma l growth factor receptor 2 (HER-2/neu) is a bi- omarker, recognized as a valuable prognostic and predictive factor for breast cancer. In approximately 20% of primary breast cancers, the HER2/neu protein is over-expressed. The effect of this over-expression is an increase in receptor mediated intracellular signalling, directing the cancer cells into fast prolifera- tion, which results in an aggressive form of breast cancer. By recent clinical re- search, a treatment procedure, with corresponding monoclonal antibodies spe- cifically designed to target the HER2/neu receptor, was confirmed. Therefore, in modern breast cancer diagnostics, accurate recognition of the HER-2/neu positive breast cancer should be provided. This can be done, first by accurate segmentation of HER-2/neu over-expressed cancer cell membranes and then, by providing corresponding membrane connectivity analysis. This paper is a con- tinuation of a previous research, in which the problem of cell membrane seg- mentation was considered. In the present study, we propose a HER-2/neu can- cer cell membrane connectivity analysis, by examining corresponding shape coefficients. We performed statistical analysis, investigating the significance of the proposed coefficients in terms of HER-2/neu cancer cell recognition pro- cess. The proposed research gives a basis for the introduction of a complete HER-2/neu breast cancer recognition procedure." @default.
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- W2294802009 date "2014-01-01" @default.
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- W2294802009 title "HER-2/neu Breast Cancer Diagnosis Procedure, Based on Histopathology Image Analysis" @default.
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