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• W2294811600 abstract "Global increases in the use of HIV antiretroviral therapy (ART) are driven, at least in part, by the efficacy of treatment as prevention of transmission, via the reduction in viral loads after the initiation of ART. 1 Cohen MS Chen YQ McCauley M et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011; 365: 493-505 Crossref PubMed Scopus (5388) Google Scholar Because reduction in viral load is central to treatment-as-prevention, it follows that an aggregate measurement of viral loads could be a useful impact evaluation measure. Community viral load was first presented as a concept in 2008, 2 Stall R. What's driving the U.S. epidemic in men who have sex with men. Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA, Feb 3–6, 2008. Google Scholar and emerged as a heuristic proxy for HIV transmission potential or level of HIV-associated health care in a given community or population. 3 Wood E Kerr T Marshall BD et al. Longitudinal community plasma HIV-1 RNA concentrations and incidence of HIV-1 among injecting drug users: prospective cohort study. BMJ. 2009; 338: b1649 Crossref PubMed Scopus (290) Google Scholar , 4 Montaner JS Lima VD Barrios R et al. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet. 2010; 376: 532-539 Summary Full Text Full Text PDF PubMed Scopus (640) Google Scholar Community viral load, as an index, is commonly defined as the mean of individual plasma viral RNA concentrations in a geographical area or population. For prevention programmes that promote reduced viral load and transmission potential as a measure of effectiveness, community viral load needs to be an informative index for comparisons through time or across communities. Community viral load, antiretroviral therapy coverage, and HIV incidence in India: a cross-sectional, comparative studyPrevalence of viraemia had the strongest correlation with HIV incidence in this sample and might be a useful measure of the effectiveness of a treatment programme. Full-Text PDF" @default.
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• W2294811600 date "2016-04-01" @default.
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• W2294811600 title "Community viral load as an index of HIV transmission potential" @default.
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