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- W2294839841 abstract "Neuropeptide-Y (NPY) is involved in the induction of immune-mediated inflammation. But, its role in atherosclerotic plaques is unknown. Here, we examined NPY-receptor(R) expression in the presence of IGF-1 and TNF-α in plaque smooth muscle cells (pSMCs) of symptomatic(S) and asymptomatic(AS) patients with carotid stenosis. IGF-1 increased NPY-Y1 and NPY-Y5 expression in S (1.5 and 1.2-fold) and AS pSMCs (2 and 1.5-fold, respectively). TNF-α significantly decreased NPY-Y1R (10-fold) in S with no change in AS pSMCs. NPY-Y5R expression decreased significantly in both S and AS pSMCs by TNF-α. The combined stimulation of the cells with IGF-1 and TNF-α increased NPY-Y1 expression by 1.2-fold in AS pSMCs but no effects in S pSMCs. In both S and AS pSMCs, IGF-1 increased NPY-Y5 expression, but the effect of IGF-1 in the presence TNF-α was abolished. IGF-1 increased (80%) NPY-Y2 receptor expression in AS pSMCs, but had no significant effect in S pSMCs. NPY-Y2 expression was higher in AS (2.5-fold) and S pSMCs (3.5-fold) upon TNF-α stimulation than respective controls. Thus, IGF-1 and TNF-α differentially modulate NPY-Y1, -Y2 and -Y5 receptor expression in AS and S pSMCs. A balance between the inflammatory cytokines and IGF-1 level at the plaque milieu is critical in determining SMC proliferation or apoptosis at the site of fibrous cap leading to the plaque stability/instability in symptomatic patients with carotid stenosis. (Supported by NIH R01HL073349)" @default.
- W2294839841 created "2016-06-24" @default.
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- W2294839841 date "2010-04-01" @default.
- W2294839841 modified "2023-09-25" @default.
- W2294839841 title "Modulation of Neuropeptide‐Y receptor expression by IGF‐1 and atheroma‐associated cytokines in carotid plaques of symptomatic and asymptomatic patients" @default.
- W2294839841 doi "https://doi.org/10.1096/fasebj.24.1_supplement.1028.2" @default.
- W2294839841 hasPublicationYear "2010" @default.
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