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- W2294846265 abstract "The construction of a three-dimensional (3D) liver tissue is limited by many factors; one of them is the lack of vascularization inside the tissue-engineered construct. An engineered liver pocket-scaffold able to increase neo-angiogenesis in vivo could be a solution to overcome these limitations. In this work, a hyaluronan (HA)-based scaffold enriched with human mesenchymal stem cells (hMSCs) and rat hepatocytes was pre-conditioned in a bioreactor system, then implanted into the liver of rats. Angiogenesis and hepatocyte metabolic functions were monitored. The formation of a de novo vascular network within the HA-based scaffold, as well as an improvement in albumin production by the implanted hepatocytes, were detected. The presence of hMSCs in the HA-scaffold increased the concentration of growth factors promoting angiogenesis inside the graft. This event ensured a high blood vessel density, coupled with a support to metabolic functions of hepatocytes. All together, these results highlight the important role played by stem cells in liver tissue-engineered engraftment." @default.
- W2294846265 created "2016-06-24" @default.
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- W2294846265 date "2016-03-12" @default.
- W2294846265 modified "2023-10-16" @default.
- W2294846265 title "Mesenchymal Stem Cells Increase Neo-Angiogenesis and Albumin Production in a Liver Tissue-Engineered Engraftment" @default.
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- W2294846265 doi "https://doi.org/10.3390/ijms17030374" @default.
- W2294846265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4813233" @default.
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