FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2294857314> ?p ?o ?g. }

• W2294857314 endingPage "3341" @default.
• W2294857314 startingPage "3330" @default.
• W2294857314 abstract "ABSTRACT In addition to infectious viral particles, hepatitis B virus-replicating cells secrete large amounts of subviral particles assembled by the surface proteins, but lacking any capsid and genome. Subviral particles form spheres (22-nm particles) and filaments. Filaments contain a much larger amount of the large surface protein (LHBs) compared to spheres. Spheres are released via the constitutive secretory pathway, while viral particles are ESCRT-dependently released via multivesicular bodies (MVBs). The interaction of virions with the ESCRT machinery is mediated by α-taxilin that connects the viral surface protein LHBs with the ESCRT component tsg101. Since filaments in contrast to spheres contain a significant amount of LHBs, it is unclear whether filaments are released like spheres or like virions. To study the release of subviral particles in the absence of virion formation, a core-deficient HBV mutant was generated. Confocal microscopy, immune electron microscopy of ultrathin sections and isolation of MVBs revealed that filaments enter MVBs. Inhibition of MVB biogenesis by the small-molecule inhibitor U18666A or inhibition of ESCRT functionality by coexpression of transdominant negative mutants (Vps4A, Vps4B, and CHMP3) abolishes the release of filaments while the secretion of spheres is not affected. These data indicate that in contrast to spheres which are secreted via the secretory pathway, filaments are released via ESCRT/MVB pathway like infectious viral particles. IMPORTANCE This study revises the current model describing the release of subviral particles by showing that in contrast to spheres, which are secreted via the secretory pathway, filaments are released via the ESCRT/MVB pathway like infectious viral particles. These data significantly contribute to a better understanding of the viral morphogenesis and might be helpful for the design of novel antiviral strategies." @default.
• W2294857314 created "2016-06-24" @default.
• W2294857314 creator A5003227244 @default.
• W2294857314 creator A5033004746 @default.
• W2294857314 creator A5060098994 @default.
• W2294857314 creator A5066212310 @default.
• W2294857314 creator A5077488891 @default.
• W2294857314 date "2016-04-01" @default.
• W2294857314 modified "2023-10-12" @default.
• W2294857314 title "Subviral Hepatitis B Virus Filaments, like Infectious Viral Particles, Are Released via Multivesicular Bodies" @default.
• W2294857314 cites W1269890246 @default.
• W2294857314 cites W1536231102 @default.
• W2294857314 cites W1544473294 @default.
• W2294857314 cites W1557805105 @default.
• W2294857314 cites W1601220883 @default.
• W2294857314 cites W1751218746 @default.
• W2294857314 cites W1970934632 @default.
• W2294857314 cites W1971689602 @default.
• W2294857314 cites W1972480731 @default.
• W2294857314 cites W1973432603 @default.
• W2294857314 cites W1976252335 @default.
• W2294857314 cites W1978141733 @default.
• W2294857314 cites W1985747385 @default.
• W2294857314 cites W1989070801 @default.
• W2294857314 cites W2007026967 @default.
• W2294857314 cites W2007311551 @default.
• W2294857314 cites W2010338556 @default.
• W2294857314 cites W2015279300 @default.
• W2294857314 cites W2023420720 @default.
• W2294857314 cites W2024879590 @default.
• W2294857314 cites W2031860444 @default.
• W2294857314 cites W2041389505 @default.
• W2294857314 cites W2043892409 @default.
• W2294857314 cites W2045893780 @default.
• W2294857314 cites W2054735667 @default.
• W2294857314 cites W2057706707 @default.
• W2294857314 cites W2061171442 @default.
• W2294857314 cites W2062115311 @default.
• W2294857314 cites W2065365365 @default.
• W2294857314 cites W2073784219 @default.
• W2294857314 cites W2074130602 @default.
• W2294857314 cites W2076684492 @default.
• W2294857314 cites W2080999677 @default.
• W2294857314 cites W2083703476 @default.
• W2294857314 cites W2084205642 @default.
• W2294857314 cites W2091589417 @default.
• W2294857314 cites W2099953885 @default.
• W2294857314 cites W2103169204 @default.
• W2294857314 cites W2105058587 @default.
• W2294857314 cites W2113985215 @default.
• W2294857314 cites W2115271408 @default.
• W2294857314 cites W2116864678 @default.
• W2294857314 cites W2117809342 @default.
• W2294857314 cites W2121799097 @default.
• W2294857314 cites W2123460928 @default.
• W2294857314 cites W2130357985 @default.
• W2294857314 cites W2130448025 @default.
• W2294857314 cites W2135719897 @default.
• W2294857314 cites W2136822273 @default.
• W2294857314 cites W2139206273 @default.
• W2294857314 cites W2145137950 @default.
• W2294857314 cites W2145823322 @default.
• W2294857314 cites W2158129085 @default.
• W2294857314 cites W2158964726 @default.
• W2294857314 cites W2172683288 @default.
• W2294857314 doi "https://doi.org/10.1128/jvi.03109-15" @default.
• W2294857314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4794700" @default.
• W2294857314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26719264" @default.
• W2294857314 hasPublicationYear "2016" @default.
• W2294857314 type Work @default.
• W2294857314 sameAs 2294857314 @default.
• W2294857314 citedByCount "74" @default.
• W2294857314 countsByYear W22948573142016 @default.
• W2294857314 countsByYear W22948573142017 @default.
• W2294857314 countsByYear W22948573142018 @default.
• W2294857314 countsByYear W22948573142019 @default.
• W2294857314 countsByYear W22948573142020 @default.
• W2294857314 countsByYear W22948573142021 @default.
• W2294857314 countsByYear W22948573142022 @default.
• W2294857314 countsByYear W22948573142023 @default.
• W2294857314 crossrefType "journal-article" @default.
• W2294857314 hasAuthorship W2294857314A5003227244 @default.
• W2294857314 hasAuthorship W2294857314A5033004746 @default.
• W2294857314 hasAuthorship W2294857314A5060098994 @default.
• W2294857314 hasAuthorship W2294857314A5066212310 @default.
• W2294857314 hasAuthorship W2294857314A5077488891 @default.
• W2294857314 hasBestOaLocation W22948573141 @default.
• W2294857314 hasConcept C102747710 @default.
• W2294857314 hasConcept C104317684 @default.
• W2294857314 hasConcept C12554922 @default.
• W2294857314 hasConcept C131934819 @default.
• W2294857314 hasConcept C143876685 @default.
• W2294857314 hasConcept C159047783 @default.
• W2294857314 hasConcept C202878990 @default.
• W2294857314 hasConcept C2522874641 @default.
• W2294857314 hasConcept C49039625 @default.
• W2294857314 hasConcept C55493867 @default.
• W2294857314 hasConcept C79879829 @default.

• next