FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2294862404> ?p ?o ?g. }

• W2294862404 abstract "Macrophages play a central role in the pathogenesis of leprosy, caused by Mycobacterium leprae. The polarized clinical presentations in leprosy are associated with differential immune activation. In tuberculoid leprosy, macrophages show a classical activation phenotype (M1), while macrophages in lepromatous disease display characteristics of alternative activation (M2). Bacille Calmette-Guérin (BCG) vaccination, which protects against leprosy, can promote sustained changes in monocyte response to unrelated pathogens and may preferentially direct monocytes towards an M1 protective phenotype. We previously reported that M. leprae can dampen the response of naïve human monocytes to a strong inducer of pro-inflammatory cytokines, such as BCG. Here, we investigated the ability of the pathogen to alter the direction of macrophage polarization and the impact of BCG vaccination on the monocyte response to M. leprae. We show that in vitro exposure of monocytes from healthy donors to M. leprae interferes with subsequent M1 polarization, indicated by lower levels of M1-associated cytokine/chemokines released and reduced expression of M1 cell surface markers. Exposure to M. leprae phenolic glycolipid (PGL) 1, instead of whole bacteria, demonstrated a similar effect on M1 cytokine/chemokine release. In addition, we found that monocytes from 10-week old BCG-vaccinated infants released higher levels of the pro-inflammatory cytokines TNF-α and IL-1β in response to M. leprae compared to those from unvaccinated infants. Exposure to M. leprae has an inhibitory effect on M1 macrophage polarization, likely mediated through PGL-1. By directing monocyte/macrophages preferentially towards M1 activation, BCG vaccination may render the cells more refractory to the inhibitory effects of subsequent M. leprae infection." @default.
• W2294862404 created "2016-06-24" @default.
• W2294862404 creator A5026896830 @default.
• W2294862404 creator A5033536490 @default.
• W2294862404 creator A5090415157 @default.
• W2294862404 creator A5091735303 @default.
• W2294862404 date "2016-03-11" @default.
• W2294862404 modified "2023-10-13" @default.
• W2294862404 title "Mycobacterium leprae alters classical activation of human monocytes in vitro" @default.
• W2294862404 cites W1568457937 @default.
• W2294862404 cites W1572384585 @default.
• W2294862404 cites W1762889570 @default.
• W2294862404 cites W1945513028 @default.
• W2294862404 cites W1962869168 @default.
• W2294862404 cites W1971965419 @default.
• W2294862404 cites W1974612149 @default.
• W2294862404 cites W1976114447 @default.
• W2294862404 cites W1978442399 @default.
• W2294862404 cites W1981017054 @default.
• W2294862404 cites W1991999800 @default.
• W2294862404 cites W2009170266 @default.
• W2294862404 cites W2016293419 @default.
• W2294862404 cites W2025216349 @default.
• W2294862404 cites W2029730125 @default.
• W2294862404 cites W2059403792 @default.
• W2294862404 cites W2083198686 @default.
• W2294862404 cites W2086343026 @default.
• W2294862404 cites W2119745788 @default.
• W2294862404 cites W2123605098 @default.
• W2294862404 cites W2128761786 @default.
• W2294862404 cites W2167126518 @default.
• W2294862404 cites W2232037017 @default.
• W2294862404 cites W2275113597 @default.
• W2294862404 cites W4378380786 @default.
• W2294862404 doi "https://doi.org/10.1186/s12950-016-0117-4" @default.
• W2294862404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4788835" @default.
• W2294862404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26973434" @default.
• W2294862404 hasPublicationYear "2016" @default.
• W2294862404 type Work @default.
• W2294862404 sameAs 2294862404 @default.
• W2294862404 citedByCount "19" @default.
• W2294862404 countsByYear W22948624042016 @default.
• W2294862404 countsByYear W22948624042017 @default.
• W2294862404 countsByYear W22948624042018 @default.
• W2294862404 countsByYear W22948624042019 @default.
• W2294862404 countsByYear W22948624042020 @default.
• W2294862404 countsByYear W22948624042021 @default.
• W2294862404 countsByYear W22948624042023 @default.
• W2294862404 crossrefType "journal-article" @default.
• W2294862404 hasAuthorship W2294862404A5026896830 @default.
• W2294862404 hasAuthorship W2294862404A5033536490 @default.
• W2294862404 hasAuthorship W2294862404A5090415157 @default.
• W2294862404 hasAuthorship W2294862404A5091735303 @default.
• W2294862404 hasBestOaLocation W22948624041 @default.
• W2294862404 hasConcept C101666144 @default.
• W2294862404 hasConcept C13373296 @default.
• W2294862404 hasConcept C202751555 @default.
• W2294862404 hasConcept C203014093 @default.
• W2294862404 hasConcept C2776682551 @default.
• W2294862404 hasConcept C2778690821 @default.
• W2294862404 hasConcept C2779244956 @default.
• W2294862404 hasConcept C2779823659 @default.
• W2294862404 hasConcept C2779846462 @default.
• W2294862404 hasConcept C2780695269 @default.
• W2294862404 hasConcept C2781184567 @default.
• W2294862404 hasConcept C55493867 @default.
• W2294862404 hasConcept C71924100 @default.
• W2294862404 hasConcept C86803240 @default.
• W2294862404 hasConcept C8891405 @default.
• W2294862404 hasConcept C89423630 @default.
• W2294862404 hasConceptScore W2294862404C101666144 @default.
• W2294862404 hasConceptScore W2294862404C13373296 @default.
• W2294862404 hasConceptScore W2294862404C202751555 @default.
• W2294862404 hasConceptScore W2294862404C203014093 @default.
• W2294862404 hasConceptScore W2294862404C2776682551 @default.
• W2294862404 hasConceptScore W2294862404C2778690821 @default.
• W2294862404 hasConceptScore W2294862404C2779244956 @default.
• W2294862404 hasConceptScore W2294862404C2779823659 @default.
• W2294862404 hasConceptScore W2294862404C2779846462 @default.
• W2294862404 hasConceptScore W2294862404C2780695269 @default.
• W2294862404 hasConceptScore W2294862404C2781184567 @default.
• W2294862404 hasConceptScore W2294862404C55493867 @default.
• W2294862404 hasConceptScore W2294862404C71924100 @default.
• W2294862404 hasConceptScore W2294862404C86803240 @default.
• W2294862404 hasConceptScore W2294862404C8891405 @default.
• W2294862404 hasConceptScore W2294862404C89423630 @default.
• W2294862404 hasFunder F4320306188 @default.
• W2294862404 hasFunder F4320332161 @default.
• W2294862404 hasIssue "1" @default.
• W2294862404 hasLocation W22948624041 @default.
• W2294862404 hasLocation W22948624042 @default.
• W2294862404 hasLocation W22948624043 @default.
• W2294862404 hasLocation W22948624044 @default.
• W2294862404 hasOpenAccess W2294862404 @default.
• W2294862404 hasPrimaryLocation W22948624041 @default.
• W2294862404 hasRelatedWork W1481036493 @default.
• W2294862404 hasRelatedWork W2005666125 @default.
• W2294862404 hasRelatedWork W2016954721 @default.
• W2294862404 hasRelatedWork W2078683391 @default.
• W2294862404 hasRelatedWork W2091404165 @default.

• next