FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2294877715> ?p ?o ?g. }

• W2294877715 endingPage "e1143996" @default.
• W2294877715 startingPage "e1143996" @default.
• W2294877715 abstract "The availability of clinical-grade cytokines and artificial antigen-presenting cells has accelerated interest in using natural killer (NK) cells as adoptive cellular therapy (ACT) for cancer. One of the technological shortcomings of translating therapies from animal models to clinical application is the inability to effectively and non-invasively track these cells after infusion in patients. We have optimized the nonradioactive isotope fluorine-19 (19F) as a means to label and track NK cells in preclinical models using magnetic resonance imaging (MRI). Human NK cells were expanded with interleukin (IL)-2 and labeled in vitro with increasing concentrations of 19F. Doses as low as 2 mg/mL 19F were detected by MRI. NK cell viability was only decreased at 8 mg/mL 19F. No effects on NK cell cytotoxicity against K562 leukemia cells were observed with 2, 4 or 8 mg/mL 19F. Higher doses of 19F, 4 mg/mL and 8 mg/mL, led to an improved 19F signal by MRI with 3 × 1011 19F atoms per NK cell. The 4 mg/mL 19F labeling had no effect on NK cell function via secretion of granzyme B or interferon gamma (IFNγ), compared to NK cells exposed to vehicle alone. 19F-labeled NK cells were detectable immediately by MRI after intratumoral injection in NSG mice and up to day 8. When 19F-labeled NK cells were injected subcutaneously, we observed a loss of signal through time at the site of injection suggesting NK cell migration to distant organs. The 19F perfluorocarbon is a safe and effective reagent for monitoring the persistence and trafficking of NK cell infusions in vivo, and may have potential for developing novel imaging techniques to monitor ACT for cancer." @default.
• W2294877715 created "2016-06-24" @default.
• W2294877715 creator A5019529832 @default.
• W2294877715 creator A5048109671 @default.
• W2294877715 creator A5048416186 @default.
• W2294877715 creator A5054397260 @default.
• W2294877715 creator A5063758678 @default.
• W2294877715 creator A5079824614 @default.
• W2294877715 creator A5070881083 @default.
• W2294877715 date "2016-02-18" @default.
• W2294877715 modified "2023-10-15" @default.
• W2294877715 title "¹⁹F-MRI for monitoring human NK cells<i>in vivo</i>" @default.
• W2294877715 cites W1575956581 @default.
• W2294877715 cites W1582713125 @default.
• W2294877715 cites W1798184081 @default.
• W2294877715 cites W1894812727 @default.
• W2294877715 cites W1925481226 @default.
• W2294877715 cites W1945062032 @default.
• W2294877715 cites W1958499971 @default.
• W2294877715 cites W1968086476 @default.
• W2294877715 cites W1992430391 @default.
• W2294877715 cites W2001048194 @default.
• W2294877715 cites W2007532980 @default.
• W2294877715 cites W2009420231 @default.
• W2294877715 cites W2013331637 @default.
• W2294877715 cites W2017769923 @default.
• W2294877715 cites W2021518982 @default.
• W2294877715 cites W2033107552 @default.
• W2294877715 cites W2035435963 @default.
• W2294877715 cites W2036088843 @default.
• W2294877715 cites W2038432511 @default.
• W2294877715 cites W2038700814 @default.
• W2294877715 cites W2039582699 @default.
• W2294877715 cites W2044103767 @default.
• W2294877715 cites W2045883564 @default.
• W2294877715 cites W2050632372 @default.
• W2294877715 cites W2051962704 @default.
• W2294877715 cites W2059022635 @default.
• W2294877715 cites W2059405564 @default.
• W2294877715 cites W2075278894 @default.
• W2294877715 cites W2076248543 @default.
• W2294877715 cites W2080613443 @default.
• W2294877715 cites W2087614330 @default.
• W2294877715 cites W2088273900 @default.
• W2294877715 cites W2092215629 @default.
• W2294877715 cites W2095426587 @default.
• W2294877715 cites W2101501385 @default.
• W2294877715 cites W2104900795 @default.
• W2294877715 cites W2111421986 @default.
• W2294877715 cites W2113811237 @default.
• W2294877715 cites W2119793652 @default.
• W2294877715 cites W2121146521 @default.
• W2294877715 cites W2121854970 @default.
• W2294877715 cites W2124169195 @default.
• W2294877715 cites W2124947137 @default.
• W2294877715 cites W2135092543 @default.
• W2294877715 cites W2136505166 @default.
• W2294877715 cites W2136681115 @default.
• W2294877715 cites W2143634092 @default.
• W2294877715 cites W2144126123 @default.
• W2294877715 cites W2144872368 @default.
• W2294877715 cites W2156664953 @default.
• W2294877715 cites W2162424471 @default.
• W2294877715 cites W2166921498 @default.
• W2294877715 cites W2170202960 @default.
• W2294877715 cites W2170379319 @default.
• W2294877715 cites W2316618557 @default.
• W2294877715 cites W272579771 @default.
• W2294877715 doi "https://doi.org/10.1080/2162402x.2016.1143996" @default.
• W2294877715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4910731" @default.
• W2294877715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27467963" @default.
• W2294877715 hasPublicationYear "2016" @default.
• W2294877715 type Work @default.
• W2294877715 sameAs 2294877715 @default.
• W2294877715 citedByCount "47" @default.
• W2294877715 countsByYear W22948777152016 @default.
• W2294877715 countsByYear W22948777152017 @default.
• W2294877715 countsByYear W22948777152018 @default.
• W2294877715 countsByYear W22948777152019 @default.
• W2294877715 countsByYear W22948777152020 @default.
• W2294877715 countsByYear W22948777152021 @default.
• W2294877715 countsByYear W22948777152022 @default.
• W2294877715 countsByYear W22948777152023 @default.
• W2294877715 crossrefType "journal-article" @default.
• W2294877715 hasAuthorship W2294877715A5019529832 @default.
• W2294877715 hasAuthorship W2294877715A5048109671 @default.
• W2294877715 hasAuthorship W2294877715A5048416186 @default.
• W2294877715 hasAuthorship W2294877715A5054397260 @default.
• W2294877715 hasAuthorship W2294877715A5063758678 @default.
• W2294877715 hasAuthorship W2294877715A5070881083 @default.
• W2294877715 hasAuthorship W2294877715A5079824614 @default.
• W2294877715 hasBestOaLocation W22948777151 @default.
• W2294877715 hasConcept C109316439 @default.
• W2294877715 hasConcept C142724271 @default.
• W2294877715 hasConcept C149532602 @default.
• W2294877715 hasConcept C150903083 @default.
• W2294877715 hasConcept C154317977 @default.
• W2294877715 hasConcept C171122931 @default.

• next