Matches in SemOpenAlex for { <https://semopenalex.org/work/W2294979059> ?p ?o ?g. }
- W2294979059 endingPage "13" @default.
- W2294979059 startingPage "13" @default.
- W2294979059 abstract "The concurrent increases in global population and sexually transmitted infection (STI) demand a search for agents with dual spermicidal and microbicidal properties for topical vaginal application. Previous attempts to develop the surfactant spermicide, nonoxynol-9 (N-9), into a vaginal microbicide were unsuccessful largely due to its inefficiency to kill microbes. Furthermore, N-9 causes damage to the vaginal epithelium, thus accelerating microbes to enter the women’s body. For this reason, antimicrobial peptides (AMPs), naturally secreted by all forms of life as part of innate immunity, deserve evaluation for their potential spermicidal effects. To date, twelve spermicidal AMPs have been described including LL-37, magainin 2 and nisin A. Human cathelicidin LL-37 is the most promising spermicidal AMP to be further developed for vaginal use for the following reasons. First, it is a human AMP naturally produced in the vagina after intercourse. Second, LL-37 exerts microbicidal effects to numerous microbes including those that cause STI. Third, its cytotoxicity is selective to sperm and not to the female reproductive tract. Furthermore, the spermicidal effects of LL-37 have been demonstrated in vivo in mice. Therefore, the availability of LL-37 as a vaginal spermicide/microbicide will empower women for self-protection against unwanted pregnancies and STI." @default.
- W2294979059 created "2016-06-24" @default.
- W2294979059 creator A5005230681 @default.
- W2294979059 creator A5007468459 @default.
- W2294979059 creator A5014244436 @default.
- W2294979059 creator A5019689255 @default.
- W2294979059 creator A5028308177 @default.
- W2294979059 creator A5032662365 @default.
- W2294979059 creator A5039255378 @default.
- W2294979059 creator A5046449541 @default.
- W2294979059 creator A5052022256 @default.
- W2294979059 creator A5067380502 @default.
- W2294979059 date "2016-03-11" @default.
- W2294979059 modified "2023-09-30" @default.
- W2294979059 title "Potential Use of Antimicrobial Peptides as Vaginal Spermicides/Microbicides" @default.
- W2294979059 cites W1504658722 @default.
- W2294979059 cites W1552825446 @default.
- W2294979059 cites W1644852485 @default.
- W2294979059 cites W1662185404 @default.
- W2294979059 cites W1672372553 @default.
- W2294979059 cites W174027079 @default.
- W2294979059 cites W1760811549 @default.
- W2294979059 cites W1797701563 @default.
- W2294979059 cites W1799680372 @default.
- W2294979059 cites W1853366991 @default.
- W2294979059 cites W1895027885 @default.
- W2294979059 cites W1924631459 @default.
- W2294979059 cites W1943160106 @default.
- W2294979059 cites W1945664147 @default.
- W2294979059 cites W1963525621 @default.
- W2294979059 cites W1963847339 @default.
- W2294979059 cites W1965311027 @default.
- W2294979059 cites W1966355489 @default.
- W2294979059 cites W1966402088 @default.
- W2294979059 cites W1968069591 @default.
- W2294979059 cites W1970345858 @default.
- W2294979059 cites W1970503287 @default.
- W2294979059 cites W1971042231 @default.
- W2294979059 cites W1971914602 @default.
- W2294979059 cites W1971989084 @default.
- W2294979059 cites W1972722060 @default.
- W2294979059 cites W1973641356 @default.
- W2294979059 cites W1974799856 @default.
- W2294979059 cites W1975048321 @default.
- W2294979059 cites W1975821399 @default.
- W2294979059 cites W1977179183 @default.
- W2294979059 cites W1977526531 @default.
- W2294979059 cites W1978513706 @default.
- W2294979059 cites W1978906326 @default.
- W2294979059 cites W1979148488 @default.
- W2294979059 cites W1979258089 @default.
- W2294979059 cites W197978049 @default.
- W2294979059 cites W1981705708 @default.
- W2294979059 cites W1984287836 @default.
- W2294979059 cites W1986224819 @default.
- W2294979059 cites W1986507006 @default.
- W2294979059 cites W1989998611 @default.
- W2294979059 cites W1990675670 @default.
- W2294979059 cites W1990697186 @default.
- W2294979059 cites W1991050217 @default.
- W2294979059 cites W1992311076 @default.
- W2294979059 cites W1992806999 @default.
- W2294979059 cites W1993287290 @default.
- W2294979059 cites W1994574697 @default.
- W2294979059 cites W1998732426 @default.
- W2294979059 cites W1998760712 @default.
- W2294979059 cites W1999530559 @default.
- W2294979059 cites W1999872376 @default.
- W2294979059 cites W2000202551 @default.
- W2294979059 cites W2001145498 @default.
- W2294979059 cites W2002195659 @default.
- W2294979059 cites W2002648188 @default.
- W2294979059 cites W2002666618 @default.
- W2294979059 cites W2004107464 @default.
- W2294979059 cites W2004654708 @default.
- W2294979059 cites W2005410289 @default.
- W2294979059 cites W2005560274 @default.
- W2294979059 cites W2007843249 @default.
- W2294979059 cites W2008345409 @default.
- W2294979059 cites W2009703524 @default.
- W2294979059 cites W2009941225 @default.
- W2294979059 cites W2010286951 @default.
- W2294979059 cites W2010666335 @default.
- W2294979059 cites W2015021843 @default.
- W2294979059 cites W2017070041 @default.
- W2294979059 cites W2017090623 @default.
- W2294979059 cites W2020051213 @default.
- W2294979059 cites W2023425836 @default.
- W2294979059 cites W2024213191 @default.
- W2294979059 cites W2024218317 @default.
- W2294979059 cites W2024679302 @default.
- W2294979059 cites W2024793749 @default.
- W2294979059 cites W2026580538 @default.
- W2294979059 cites W2027274633 @default.
- W2294979059 cites W2028259820 @default.
- W2294979059 cites W2028439279 @default.
- W2294979059 cites W2028501275 @default.
- W2294979059 cites W2029431294 @default.