FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2294985544> ?p ?o ?g. }

• W2294985544 endingPage "84" @default.
• W2294985544 startingPage "78" @default.
• W2294985544 abstract "Melanogenesis is a physiological process that results in the synthesis of melanin pigments, which play a crucial protective role against skin photocarcinogenesis. We investigated the effects of a Polygoni Multiflori Ramulus extract on melanogenesis and isolated emodin from Polygoni Multiflori as an active compound. In addition, the possible mechanisms of action were examined. We found that emodin inhibited both melanin content and tyrosinase activity concentration and time dependently. Tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 mRNA levels decreased following emodin treatment. However, while the mRNA levels of microphthalmia-associated transcription factor (MITF) were not affected by emodin, emodin reduced MITF protein levels. Furthermore, expression of the liver X-receptor (LXR) α gene, but not the LXR β gene was upregulated by emodin. Moreover, emodin regulated melanogenesis by promoting degradation of the MITF protein by upregulating the LXR α gene. The emodin effects on MITF was found to be mediated by phosphorylation of p42/44 MAPK. Taken together, these findings indicate that the inhibition of melanogenesis by emodin occurs through reduced MITF protein expression, which is mediated by upregulation of the LXR α gene and suggest that emodin may be useful as a hyperpigmentation inhibitor." @default.
• W2294985544 created "2016-06-24" @default.
• W2294985544 creator A5015536743 @default.
• W2294985544 creator A5030853463 @default.
• W2294985544 creator A5049032346 @default.
• W2294985544 creator A5051405944 @default.
• W2294985544 creator A5067891772 @default.
• W2294985544 creator A5069434189 @default.
• W2294985544 creator A5077132260 @default.
• W2294985544 creator A5080833380 @default.
• W2294985544 creator A5082289487 @default.
• W2294985544 creator A5085943012 @default.
• W2294985544 date "2016-04-01" @default.
• W2294985544 modified "2023-09-26" @default.
• W2294985544 title "Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway" @default.
• W2294985544 cites W1589763275 @default.
• W2294985544 cites W1621263861 @default.
• W2294985544 cites W171379405 @default.
• W2294985544 cites W1962982449 @default.
• W2294985544 cites W1975903787 @default.
• W2294985544 cites W1988912859 @default.
• W2294985544 cites W1988967018 @default.
• W2294985544 cites W1992012112 @default.
• W2294985544 cites W2014233524 @default.
• W2294985544 cites W2022083096 @default.
• W2294985544 cites W2023921675 @default.
• W2294985544 cites W2029974754 @default.
• W2294985544 cites W2047814493 @default.
• W2294985544 cites W2052429604 @default.
• W2294985544 cites W2056879969 @default.
• W2294985544 cites W2064112442 @default.
• W2294985544 cites W2069413718 @default.
• W2294985544 cites W2079028949 @default.
• W2294985544 cites W2079347472 @default.
• W2294985544 cites W2080254988 @default.
• W2294985544 cites W2083773309 @default.
• W2294985544 cites W2085482737 @default.
• W2294985544 cites W2085908398 @default.
• W2294985544 cites W2092702226 @default.
• W2294985544 cites W2126638912 @default.
• W2294985544 cites W2166796677 @default.
• W2294985544 doi "https://doi.org/10.1016/j.cbi.2016.03.014" @default.
• W2294985544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26972667" @default.
• W2294985544 hasPublicationYear "2016" @default.
• W2294985544 type Work @default.
• W2294985544 sameAs 2294985544 @default.
• W2294985544 citedByCount "10" @default.
• W2294985544 countsByYear W22949855442017 @default.
• W2294985544 countsByYear W22949855442018 @default.
• W2294985544 countsByYear W22949855442019 @default.
• W2294985544 countsByYear W22949855442020 @default.
• W2294985544 countsByYear W22949855442021 @default.
• W2294985544 countsByYear W22949855442022 @default.
• W2294985544 crossrefType "journal-article" @default.
• W2294985544 hasAuthorship W2294985544A5015536743 @default.
• W2294985544 hasAuthorship W2294985544A5030853463 @default.
• W2294985544 hasAuthorship W2294985544A5049032346 @default.
• W2294985544 hasAuthorship W2294985544A5051405944 @default.
• W2294985544 hasAuthorship W2294985544A5067891772 @default.
• W2294985544 hasAuthorship W2294985544A5069434189 @default.
• W2294985544 hasAuthorship W2294985544A5077132260 @default.
• W2294985544 hasAuthorship W2294985544A5080833380 @default.
• W2294985544 hasAuthorship W2294985544A5082289487 @default.
• W2294985544 hasAuthorship W2294985544A5085943012 @default.
• W2294985544 hasConcept C104317684 @default.
• W2294985544 hasConcept C107538193 @default.
• W2294985544 hasConcept C127561419 @default.
• W2294985544 hasConcept C167400880 @default.
• W2294985544 hasConcept C177504595 @default.
• W2294985544 hasConcept C181199279 @default.
• W2294985544 hasConcept C184235292 @default.
• W2294985544 hasConcept C185592680 @default.
• W2294985544 hasConcept C2778248515 @default.
• W2294985544 hasConcept C2779078452 @default.
• W2294985544 hasConcept C45904493 @default.
• W2294985544 hasConcept C55493867 @default.
• W2294985544 hasConcept C63932345 @default.
• W2294985544 hasConcept C86339819 @default.
• W2294985544 hasConcept C86803240 @default.
• W2294985544 hasConcept C87554066 @default.
• W2294985544 hasConcept C97029542 @default.
• W2294985544 hasConcept C98274493 @default.
• W2294985544 hasConceptScore W2294985544C104317684 @default.
• W2294985544 hasConceptScore W2294985544C107538193 @default.
• W2294985544 hasConceptScore W2294985544C127561419 @default.
• W2294985544 hasConceptScore W2294985544C167400880 @default.
• W2294985544 hasConceptScore W2294985544C177504595 @default.
• W2294985544 hasConceptScore W2294985544C181199279 @default.
• W2294985544 hasConceptScore W2294985544C184235292 @default.
• W2294985544 hasConceptScore W2294985544C185592680 @default.
• W2294985544 hasConceptScore W2294985544C2778248515 @default.
• W2294985544 hasConceptScore W2294985544C2779078452 @default.
• W2294985544 hasConceptScore W2294985544C45904493 @default.
• W2294985544 hasConceptScore W2294985544C55493867 @default.
• W2294985544 hasConceptScore W2294985544C63932345 @default.
• W2294985544 hasConceptScore W2294985544C86339819 @default.
• W2294985544 hasConceptScore W2294985544C86803240 @default.
• W2294985544 hasConceptScore W2294985544C87554066 @default.

• next