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- W2295005828 abstract "Despite advances in functional neural imaging, penetrating microelectrodes provide the most direct interface for theextraction of neural signals from the nervous system and are a critical component of many high degree-of-freedom braincomputerinterface devices. Electrode insertion is a traumatic event that elicits a complex neuroinflammatory response.In this investigation we applied optical coherence microscopy (OCM), particularly optical coherence angiography(OCA), to characterize the immediate tissue response during microelectrode insertion. Microelectrodes of varyingdimension and footprint (one-, two-, and four-shank) were inserted into mouse motor cortex beneath a window aftercraniotomy surgery. The microelectrodes were inserted in 3-4 steps at 15-20°, with approximately 250 μm linearinsertion distance for each step. Before insertion and between each step, OCM datasets were collected, including forquantitative capillary velocimetry. A cohort of control animals without microelectrode insertion was also imaged over asimilar time period (2-3 hours). Mechanical tissue deformation was observed in all the experimental animals. Thequantitative angiography results varied across animals, and were not correlated with device dimensions. In some cases,localized flow drop-out was observed in a small region surrounding the electrode, while in other instances a globaldisruption in flow occurred, perhaps as a result of large vessel compression caused by mechanical pressure. OCM is atool that can be used in various neurophotonics applications, including quantification of the neuroinflammatory responseto penetrating electrode insertion." @default.
- W2295005828 created "2016-06-24" @default.
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- W2295005828 date "2016-03-09" @default.
- W2295005828 modified "2023-09-23" @default.
- W2295005828 title "Acute changes associated with electrode insertion measured with optical coherence microscopy" @default.
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- W2295005828 doi "https://doi.org/10.1117/12.2213073" @default.
- W2295005828 hasPublicationYear "2016" @default.
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