Matches in SemOpenAlex for { <https://semopenalex.org/work/W2295096054> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2295096054 endingPage "42" @default.
- W2295096054 startingPage "37" @default.
- W2295096054 abstract "The enhanced expression of glucosylceramide-based glycosphingolipids (GSLs) is a hallmark of many forms of renal disease including diabetic nephropathy, polycystic kidney disease and renal cell carcinoma. A common feature of each of these renal disorders is the preference metabolism via aerobic glycolysis. While aerobic glycolysis is an inefficient way to generate ATP, aerobic glycolysis promotes the formation of substrates important for the production of biomass, including lipids, amino acids and nucleotides, through the pentose phosphate pathway. Two products that are essential for the synthesis of glucosylceramide and more complex GSLs are generated through the pentose phosphate pathway. These products are reducing equivalents in the form of NADPH and UDP-glucose. In experimental models of each of these disorders, inhibition of glucosylceramide synthase with eliglustat or related analogues reverses the disease phenotype suggesting that blocking GSL synthesis should be explored as a potential treatment strategy." @default.
- W2295096054 created "2016-06-24" @default.
- W2295096054 creator A5072799468 @default.
- W2295096054 date "2016-01-01" @default.
- W2295096054 modified "2023-10-15" @default.
- W2295096054 title "Targeting Glycosphingolipid Metabolism to Treat Kidney Disease" @default.
- W2295096054 cites W1751530372 @default.
- W2295096054 cites W1889397865 @default.
- W2295096054 cites W1966316647 @default.
- W2295096054 cites W1991190121 @default.
- W2295096054 cites W1996116737 @default.
- W2295096054 cites W2015249167 @default.
- W2295096054 cites W2020073886 @default.
- W2295096054 cites W2021505229 @default.
- W2295096054 cites W2028703911 @default.
- W2295096054 cites W2032072281 @default.
- W2295096054 cites W2069816309 @default.
- W2295096054 cites W2091739490 @default.
- W2295096054 cites W2094632651 @default.
- W2295096054 cites W2097259163 @default.
- W2295096054 cites W2097776291 @default.
- W2295096054 cites W2100260504 @default.
- W2295096054 cites W2138948114 @default.
- W2295096054 cites W2144615875 @default.
- W2295096054 cites W2166728634 @default.
- W2295096054 cites W2281626271 @default.
- W2295096054 doi "https://doi.org/10.1159/000444926" @default.
- W2295096054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5292033" @default.
- W2295096054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26954668" @default.
- W2295096054 hasPublicationYear "2016" @default.
- W2295096054 type Work @default.
- W2295096054 sameAs 2295096054 @default.
- W2295096054 citedByCount "16" @default.
- W2295096054 countsByYear W22950960542016 @default.
- W2295096054 countsByYear W22950960542017 @default.
- W2295096054 countsByYear W22950960542018 @default.
- W2295096054 countsByYear W22950960542019 @default.
- W2295096054 countsByYear W22950960542020 @default.
- W2295096054 countsByYear W22950960542022 @default.
- W2295096054 countsByYear W22950960542023 @default.
- W2295096054 crossrefType "journal-article" @default.
- W2295096054 hasAuthorship W2295096054A5072799468 @default.
- W2295096054 hasBestOaLocation W22950960541 @default.
- W2295096054 hasConcept C103432212 @default.
- W2295096054 hasConcept C126322002 @default.
- W2295096054 hasConcept C181199279 @default.
- W2295096054 hasConcept C20251656 @default.
- W2295096054 hasConcept C2776931407 @default.
- W2295096054 hasConcept C2779134260 @default.
- W2295096054 hasConcept C2780145431 @default.
- W2295096054 hasConcept C3409486 @default.
- W2295096054 hasConcept C55493867 @default.
- W2295096054 hasConcept C55885012 @default.
- W2295096054 hasConcept C62231903 @default.
- W2295096054 hasConcept C71924100 @default.
- W2295096054 hasConcept C86803240 @default.
- W2295096054 hasConceptScore W2295096054C103432212 @default.
- W2295096054 hasConceptScore W2295096054C126322002 @default.
- W2295096054 hasConceptScore W2295096054C181199279 @default.
- W2295096054 hasConceptScore W2295096054C20251656 @default.
- W2295096054 hasConceptScore W2295096054C2776931407 @default.
- W2295096054 hasConceptScore W2295096054C2779134260 @default.
- W2295096054 hasConceptScore W2295096054C2780145431 @default.
- W2295096054 hasConceptScore W2295096054C3409486 @default.
- W2295096054 hasConceptScore W2295096054C55493867 @default.
- W2295096054 hasConceptScore W2295096054C55885012 @default.
- W2295096054 hasConceptScore W2295096054C62231903 @default.
- W2295096054 hasConceptScore W2295096054C71924100 @default.
- W2295096054 hasConceptScore W2295096054C86803240 @default.
- W2295096054 hasIssue "1" @default.
- W2295096054 hasLocation W22950960541 @default.
- W2295096054 hasLocation W22950960542 @default.
- W2295096054 hasLocation W22950960543 @default.
- W2295096054 hasLocation W22950960544 @default.
- W2295096054 hasOpenAccess W2295096054 @default.
- W2295096054 hasPrimaryLocation W22950960541 @default.
- W2295096054 hasRelatedWork W1546997066 @default.
- W2295096054 hasRelatedWork W1863592549 @default.
- W2295096054 hasRelatedWork W2072049884 @default.
- W2295096054 hasRelatedWork W2202367886 @default.
- W2295096054 hasRelatedWork W2393779090 @default.
- W2295096054 hasRelatedWork W2410805819 @default.
- W2295096054 hasRelatedWork W2420885858 @default.
- W2295096054 hasRelatedWork W2468753042 @default.
- W2295096054 hasRelatedWork W562253404 @default.
- W2295096054 hasRelatedWork W75334843 @default.
- W2295096054 hasVolume "134" @default.
- W2295096054 isParatext "false" @default.
- W2295096054 isRetracted "false" @default.
- W2295096054 magId "2295096054" @default.
- W2295096054 workType "article" @default.