FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2295106086> ?p ?o ?g. }

• W2295106086 endingPage "e3058" @default.
• W2295106086 startingPage "e3058" @default.
• W2295106086 abstract "Sensory symptoms are frequent nonmotor complaints in patients with Parkinson's disease (PD). However, few investigations integrally explored the physiology and pathology of the thermonociceptive pathway in PD. We aim to investigate the involvement of the thermonociceptive pathway in PD. Twenty-eight PD patients (16 men, with a mean age and standard deviation of 65.6 ± 10.7 years) free of neuropathic symptoms and systemic disorders were recruited for the study and compared to 23 age- and gender-matched control subjects (12 men, with a mean age and standard deviation of 65.1 ± 9.9 years). We performed skin biopsy, contact heat-evoked potential (CHEP), and quantitative sensory tests (QST) to study the involvement of the thermonociceptive pathway in PD. The duration of PD was 7.1 ± 3.2 (range 2–17 years) years and the UPDRS part III score was 25.6 ± 9.7 (range 10–48) during the off period. Compared to control subjects, PD patients had reduced intra-epidermal nerve fiber (IENF) density (2.48 ± 1.65 vs 6.36 ± 3.19 fibers/mm, P < 0.001) and CHEP amplitude (18.02 ± 10.23 vs 33.28 ± 10.48 μV, P < 0.001). Twenty-three patients (82.1%) had abnormal IENF densities and 18 (64.3%) had abnormal CHEP. Nine patients (32.1%) had abnormal thermal thresholds in the feet. In total 27 patients (96.4%) had at least 1 abnormality in IENF, CHEP, or thermal thresholds of the foot, indicating dysfunctions in the small-fiber nerve system. In control subjects, CHEP amplitude linearly correlated with IENF density (P < 0.001). In contrast, this relationship disappeared in PD (P = 0.312) and CHEP amplitude was negatively correlated with motor severity of PD independent of age, gender, and anti-PD medication dose (P = 0.036), suggesting the influences of central components on thermonociceptive systems in addition to peripheral small-fiber nerves in PD. The present study suggested impairment of small-fiber sensory system at both peripheral and central levels is an intrinsic feature of PD, and skin biopsy, CHEP, and QST provided an integral approach for assessing such dysfunctions." @default.
• W2295106086 created "2016-06-24" @default.
• W2295106086 creator A5010386600 @default.
• W2295106086 creator A5017810039 @default.
• W2295106086 creator A5023819747 @default.
• W2295106086 creator A5026465853 @default.
• W2295106086 creator A5058088922 @default.
• W2295106086 creator A5067684202 @default.
• W2295106086 creator A5067949957 @default.
• W2295106086 creator A5085377657 @default.
• W2295106086 creator A5087356344 @default.
• W2295106086 date "2016-03-01" @default.
• W2295106086 modified "2023-10-15" @default.
• W2295106086 title "Pathophysiology of Small-Fiber Sensory System in Parkinson's Disease" @default.
• W2295106086 cites W1873542579 @default.
• W2295106086 cites W1946321151 @default.
• W2295106086 cites W1966962735 @default.
• W2295106086 cites W1967452714 @default.
• W2295106086 cites W1972331674 @default.
• W2295106086 cites W1975981678 @default.
• W2295106086 cites W1978770786 @default.
• W2295106086 cites W1981724904 @default.
• W2295106086 cites W1995623204 @default.
• W2295106086 cites W2002289659 @default.
• W2295106086 cites W2003438491 @default.
• W2295106086 cites W2012206023 @default.
• W2295106086 cites W2023678963 @default.
• W2295106086 cites W2033596507 @default.
• W2295106086 cites W2036764555 @default.
• W2295106086 cites W2050505501 @default.
• W2295106086 cites W2055437008 @default.
• W2295106086 cites W2056145524 @default.
• W2295106086 cites W2061654978 @default.
• W2295106086 cites W2066266944 @default.
• W2295106086 cites W2068862426 @default.
• W2295106086 cites W2072475500 @default.
• W2295106086 cites W2073222492 @default.
• W2295106086 cites W2073449985 @default.
• W2295106086 cites W2077618912 @default.
• W2295106086 cites W2078862699 @default.
• W2295106086 cites W2085013861 @default.
• W2295106086 cites W2086787317 @default.
• W2295106086 cites W2097447145 @default.
• W2295106086 cites W2100986954 @default.
• W2295106086 cites W2114148333 @default.
• W2295106086 cites W2114249592 @default.
• W2295106086 cites W2133664995 @default.
• W2295106086 cites W2140296969 @default.
• W2295106086 cites W2153898363 @default.
• W2295106086 cites W2156411508 @default.
• W2295106086 cites W2160569512 @default.
• W2295106086 cites W2165527956 @default.
• W2295106086 cites W2166611524 @default.
• W2295106086 cites W2167278768 @default.
• W2295106086 doi "https://doi.org/10.1097/md.0000000000003058" @default.
• W2295106086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4998916" @default.
• W2295106086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26962835" @default.
• W2295106086 hasPublicationYear "2016" @default.
• W2295106086 type Work @default.
• W2295106086 sameAs 2295106086 @default.
• W2295106086 citedByCount "17" @default.
• W2295106086 countsByYear W22951060862017 @default.
• W2295106086 countsByYear W22951060862019 @default.
• W2295106086 countsByYear W22951060862020 @default.
• W2295106086 countsByYear W22951060862021 @default.
• W2295106086 countsByYear W22951060862023 @default.
• W2295106086 crossrefType "journal-article" @default.
• W2295106086 hasAuthorship W2295106086A5010386600 @default.
• W2295106086 hasAuthorship W2295106086A5017810039 @default.
• W2295106086 hasAuthorship W2295106086A5023819747 @default.
• W2295106086 hasAuthorship W2295106086A5026465853 @default.
• W2295106086 hasAuthorship W2295106086A5058088922 @default.
• W2295106086 hasAuthorship W2295106086A5067684202 @default.
• W2295106086 hasAuthorship W2295106086A5067949957 @default.
• W2295106086 hasAuthorship W2295106086A5085377657 @default.
• W2295106086 hasAuthorship W2295106086A5087356344 @default.
• W2295106086 hasBestOaLocation W22951060861 @default.
• W2295106086 hasConcept C10162356 @default.
• W2295106086 hasConcept C105702510 @default.
• W2295106086 hasConcept C118552586 @default.
• W2295106086 hasConcept C126322002 @default.
• W2295106086 hasConcept C169760540 @default.
• W2295106086 hasConcept C2775934546 @default.
• W2295106086 hasConcept C2776823239 @default.
• W2295106086 hasConcept C2779134260 @default.
• W2295106086 hasConcept C2779734285 @default.
• W2295106086 hasConcept C2780439664 @default.
• W2295106086 hasConcept C2909026353 @default.
• W2295106086 hasConcept C50965678 @default.
• W2295106086 hasConcept C71924100 @default.
• W2295106086 hasConcept C86803240 @default.
• W2295106086 hasConcept C94487597 @default.
• W2295106086 hasConceptScore W2295106086C10162356 @default.
• W2295106086 hasConceptScore W2295106086C105702510 @default.
• W2295106086 hasConceptScore W2295106086C118552586 @default.
• W2295106086 hasConceptScore W2295106086C126322002 @default.
• W2295106086 hasConceptScore W2295106086C169760540 @default.
• W2295106086 hasConceptScore W2295106086C2775934546 @default.

• next