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- W2295192013 abstract "In this thesis, the possible protective effect of frequent blood donation on cardiovascular disease was studied. Previous research has shown that high iron stores could have damaging effects on developing cardiovascular disease, and that blood donation lowers iron stores. Lowering iron stores through blood donation could therefore reduce cardiovascular disease risk.Apart from the effects on insulin resistance, metabolic syndrome, and subclinical atherosclerosis, the effects on cardiovascular morbidity and –mortality were also studied. For this purpose, data of Dutch blood donors were linked to hospital discharges and death certificates as registered at Statistics Netherlands (CBS). Within the group of people that have remained an active donor for at least 10 years, high-frequency donors (> 20 donations in men, >15 donations in women) have a significantly lower cardiovascular risk than low-frequency donors (<15 donations in men, <12 donations in women). Women appeared to have a 10% lower risk on cardiovascular disease incidence, and even 17% on cardiovascular death. Frequent blood donors are relatively healthy compared to the general population, and high-frequency donors could already have been healthier than low-frequency donors. This Healthy Donor Effect could have influenced the results. Therefore, further research on the protective effect of blood donation on cardiovascular disease is needed. Future research focussed on replicating these results, as well as the underlying causal mechanism, should take differences between men and women into account." @default.
- W2295192013 created "2016-06-24" @default.
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- W2295192013 date "2015-01-01" @default.
- W2295192013 modified "2023-09-23" @default.
- W2295192013 title "Blood donation and cardiovascular disease. Addressing the healthy donor effect" @default.
- W2295192013 hasPublicationYear "2015" @default.
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