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- W2295392443 endingPage "35" @default.
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- W2295392443 abstract "To realize the full potential of cancer immunotherapy, the latest generation immunotherapeutics are designed to harness the potent tumor-killing capacity of T cells. Thus, to mobilize T cells, new optimized bispecific antibody (BsAb) designs, enabling efficient polyclonal redirection of cytotoxic activity through binding to CD3 and a Tumor Associated Antigen (TAA) and refined genetically modified T cells have recently expanded the arsenal of available options for cancer treatment. This review presents the current understanding of the parameters crucial to the design of optimal T cell redirecting BsAb and chimeric antigen receptor (CAR)-modified T cells. However, there are additional questions that require thorough elucidation. Both modalities will benefit from design changes that may increase the therapeutic window. One such approach could employ the discrimination afforded by multiple TAA to significantly increase selectivity." @default.
- W2295392443 created "2016-06-24" @default.
- W2295392443 creator A5020889871 @default.
- W2295392443 creator A5029763484 @default.
- W2295392443 creator A5067216355 @default.
- W2295392443 date "2016-06-01" @default.
- W2295392443 modified "2023-09-23" @default.
- W2295392443 title "Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection" @default.
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