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- W2295405552 abstract "A 1,2-regioselective reduction of α,β-unsaturated ketones to their corresponding allylic alcohols is accomplished with NaBH4 in the presence of acidic activated alumina rehydrated to the Brockmann II grade by adding 3 % w/w water. The substrate scope includes eight ketones reduced in high regio- and diastereoselectivity to their corresponding allylic alcohols. This is the first example of the strategy of systematically tuning the surface chemistry of alumina via partial rehydration in order to modulate selectivity in a reaction. Alumina is an appealing alternative to the common Luche reduction additive, CeCl3, from the perspective of cost and procedural simplicity." @default.
- W2295405552 created "2016-06-24" @default.
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- W2295405552 date "2016-06-01" @default.
- W2295405552 modified "2023-09-27" @default.
- W2295405552 title "Cerium-free Luche reduction directed by rehydrated alumina" @default.
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- W2295405552 doi "https://doi.org/10.1016/j.tet.2016.03.017" @default.
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