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- W2295435618 abstract "Primate retrosplenial cortex (RSC) is important for memory but patient neuropathologies are diffuse so its key contributions to memory remain elusive. This study provides the first causal evidence that RSC in macaque monkeys is crucial for postoperative retention of preoperatively and postoperatively acquired memories. Preoperatively, monkeys learned 300 object-in-place scene discriminations across sessions. After RSC removal, one-trial postoperative retention tests revealed significant retrograde memory loss for these 300 discriminations relative to unoperated control monkeys. Less robust evidence was found for a deficit in anterograde memory (new postoperative learning) after RSC lesions as new learning to criterion measures failed to reveal any significant learning impairment. However, after achieving ≥90% learning criterion for the postoperatively presented novel 100 object-in-place scene discriminations, short-term retention (i.e., measured after 24 h delay) of this well-learnt set was impaired in the RSC monkeys relative to controls. A further experiment assessed rapid within session acquisition of novel object-in-place scene discriminations, again confirming that new learning per se was unimpaired by bilateral RSC removal. Primate RSC contributes critically to memory by supporting normal retention of information, even when this information does not involve an autobiographical component." @default.
- W2295435618 created "2016-06-24" @default.
- W2295435618 creator A5001319366 @default.
- W2295435618 creator A5010419748 @default.
- W2295435618 date "2016-03-05" @default.
- W2295435618 modified "2023-10-10" @default.
- W2295435618 title "Retrosplenial Cortical Contributions to Anterograde and Retrograde Memory in the Monkey" @default.
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- W2295435618 doi "https://doi.org/10.1093/cercor/bhw054" @default.
- W2295435618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4869821" @default.
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